85205-49-8
Chemical Structure
Noxiustoxin
- CAS. Nr.: 85205-49-8
- Formula:C174H286N52O54S7
- Molecular Weight:4195.00
InChIKey: VNWKTOKETHGBQD-UHFFFAOYSA-N
SMILES: O=C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(NCC(N[C@H]1CCCCN)=O)=O)=O)=O)NC2=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N3[C@@H](CCC3)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]4CCCCN)=O)NC1=O)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N5[C@@H](CCC5)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(N)=O)C(N)=O)=O)=O)=O)NC4=O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC7=CC=C(C=C7)O)C(NCC(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](C)C(NCC(N[C@@H](C)C(N[C@H]2CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N
Biological Activity: Noxiustoxin is a toxin from the venom of the Mexican scorpion Centruroides noxius which block voltage-dependent potassium channel (Kv1.3, IC50 = 360 nM), and calcium-activated potassium channel. Noxiustoxin plays an important role in neuroinflammatory disease[1][2].
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Noxiustoxin | Noxiustoxin is a toxin from the venom of the Mexican scorpion Centruroides noxius which block voltage-dependent potassium channel (Kv1.3, IC50 = 360 nM), and calcium-activated potassium channel. Noxiustoxin plays an important role in neuroinflammatory disease. | |||||||||||||||||||||
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References
- [1]. M Dauplais, et al. Determination of the Three-Dimensional Solution Structure of Noxiustoxin: Analysis of Structural Differences with Related Short-Chain Scorpion Toxins. Biochemistry.1995 Dec 26;34(51):16563-73. [Content Brief]
- [2]. H H Valdivia, et al. Charybdotoxin and noxiustoxin, two homologous peptide inhibitors of the K+(Ca2+) channel. FEBS Lett. 1988 Jan 4;226(2):280-4. [Content Brief]
