857876-30-3
857876-30-3
Chemical Structure
Motesanib Diphosphate
Synonym(s): AMG 706 Diphosphate
- CAS 番号: 857876-30-3
- Formula:C22H29N5O9P2
- Molecular Weight:569.44
IUPAC Name: N-(3,3-dimethylindolin-6-yl)-2-((pyridin-4-ylmethyl)amino)nicotinamide bis(phosphate)
InChIKey: ONDPWWDPQDCQNJ-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CN=C1NCC2=CC=NC=C2)NC3=CC(NCC4(C)C)=C4C=C3.O=P(O)(O)O.O=P(O)(O)O
Biological Activity: Motesanib Diphosphate (AMG 706 Diphosphate) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50s of 2 nM/3 nM/6 nM, respectively, and has similar activity against Kit, and is approximately 10-fold more selective for VEGFR than PDGFR and Ret.
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Motesanib Diphosphate | 99.86% | Motesanib Diphosphate (AMG 706 Diphosphate) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50s of 2 nM/3 nM/6 nM, respectively, and has similar activity against Kit, and is approximately 10-fold more selective for VEGFR than PDGFR and Ret. | ||||||||||||||||||||
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Motesanib Diphosphate (Standard) | ≥98% | Motesanib (Diphosphate) (Standard) is the analytical standard of Motesanib (Diphosphate). This product is intended for research and analytical applications. Motesanib Diphosphate (AMG 706 Diphosphate) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50s of 2 nM/3 nM/6 nM, respectively, and has similar activity against Kit, and is approximately 10-fold more selective for VEGFR than PDGFR and Ret. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.87
HY-10228RMotesanib (Standard) -
Similarity Score 0.54
HY-13342SApatinib-d8 hydrochloride -
Similarity Score 0.54
HY-13342ASApatinib-d8 free base -
Similarity Score 0.51
HY-101219VEGFR-IN-1 -
Similarity Score 0.51
HY-19986AAL993 -
Similarity Score 0.48
HY-15333ZK-261991 -
Similarity Score 0.46
HY-147375Bromodomain inhibitor-10 -
Similarity Score 0.46
HY-126146PKC-iota inhibitor 1 -
Similarity Score 0.46
HY-13999A1Amdiglurax phosphate -
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