860002-95-5
Chemical Structure
VUF5834
- CAS No.: 860002-95-5
- Formula:C31H41N5O2
- Molecular Weight:515.69
IUPAC Name: N-(1-(3-(4-cyanophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)-N-(2-(dimethylamino)ethyl)decanamide
InChIKey: KTSFPXCHLDGJCF-UHFFFAOYSA-N
SMILES: CCCCCCCCCC(N(CCN(C)C)C(C)C(N1C2=CC=C(C=C2)C#N)=NC3=C(C1=O)C=CC=C3)=O
Biological Activity: VUF5834 is a non-peptide chemokine receptor CXCR3 antagonist with non-competitive antagonistic and inverse agonistic activities. VUF5834 blocks the effects of CXCL10 and CXCL11 on human CXCR3, exhibits non-competitive antagonistic and inverse agonistic properties to CXCR3, and, except for TAK-779, has a slightly lower affinity for rodent CXCR3 than for primate CXCR3.
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VUF5834 | VUF5834 is a non-peptide chemokine receptor CXCR3 antagonist with non-competitive antagonistic and inverse agonistic activities. VUF5834 blocks the effects of CXCL10 and CXCL11 on human CXCR3, exhibits non-competitive antagonistic and inverse agonistic properties to CXCR3, and, except for TAK-779, has a slightly lower affinity for rodent CXCR3 than for primate CXCR3. | |||||||||||||||||||||
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