863564-24-3
Chemical Structure
HSD17B13-IN-2
- CAS No.: 863564-24-3
- Formula:C21H23F2NO4
- Molecular Weight:391.41
InChIKey: GPSLYTIDVZDODP-HNSKJHPRSA-N
SMILES: O=C(NC[C@]1(O)CC[C@H](COC2=CC=CC=C2F)CC1)C3=CC(F)=C(O)C=C3
Biological Activity: HSD17B13-IN-2 is an HSD17B13 inhibitor with human IC50 values of 0.18 μM (with β-estradiol as substrate) and 0.25 μM (with Leukotriene B4 as substrate), and it exhibits selectivity for human HSD17B11. HSD17B13-IN-2 binds to the active site of HSD17B13 in an NAD+-dependent manner, interacts with the bound NAD+ cofactor, and stabilizes human HSD17B13 protein to prevent its aggregation. HSD17B13-IN-2 reduces the conversion of β-estradiol to estrone in cellular assays. HSD17B13-IN-2 can be used in studies related to nonalcoholic fatty liver disease[1].
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HSD17B13-IN-2 | 99.72% | HSD17B13-IN-2 is an HSD17B13 inhibitor with human IC50 values of 0.18 μM (with β-estradiol as substrate) and 0.25 μM (with Leukotriene B4 as substrate), and it exhibits selectivity for human HSD17B11. HSD17B13-IN-2 binds to the active site of HSD17B13 in an NAD+-dependent manner, interacts with the bound NAD+ cofactor, and stabilizes human HSD17B13 protein to prevent its aggregation. HSD17B13-IN-2 reduces the conversion of β-estradiol to estrone in cellular assays. HSD17B13-IN-2 can be used in studies related to nonalcoholic fatty liver disease. | ||||||||||||||||||||
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Keywords
