869769-98-2
869769-98-2
Chemical Structure
INCB9471
- CAS No.: 869769-98-2
- Formula:C30H40F3N5O2
- Molecular Weight:559.67
IUPAC Name: (4,6-dimethylpyrimidin-5-yl)(4-((S)-4-((1R,2R)-2-ethoxy-5-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl)-3-methylpiperazin-1-yl)-4-methylpiperidin-1-yl)methanone
InChIKey: ZMCJFJZOSKEMOM-DNKZPPIMSA-N
SMILES: CCO[C@H]1[C@H](N2[C@H](CN(C3(CCN(CC3)C(C4=C(C)N=CN=C4C)=O)C)CC2)C)C5=CC=C(C(F)(F)F)C=C5C1
Biological Activity: INCB9471 is a potent, selective and orally active CCR5 antagonist. INCB9471 shows anti-HIV-1 activity[1][2].
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INCB9471 | INCB9471 is a potent, selective and orally active CCR5 antagonist. INCB9471 shows anti-HIV-1 activity. | |||||||||||||||||||||
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References
- [1]. Shin N, et al. Identification and characterization of INCB9471, an allosteric noncompetitive small-molecule antagonist of C-C chemokine receptor 5 with potent inhibitory activity against monocyte migration and HIV-1 infection. J Pharmacol Exp Ther. 2011 Jul;338(1):228-39. [Content Brief]
- [2]. Xue CB, et al. Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity. ACS Med Chem Lett. 2010 Aug 25;1(9):483-7. [Content Brief]
Keywords
