87155-77-9
Chemical Structure
D-Ala-D-Ala TFA
Synonym(s): D-Alanyl-D-alanine TFA; H-D-Ala-D-Ala-OH TFA
- CAS No.: 87155-77-9
- Formula:C8H13F3N2O5
- Molecular Weight:274.20
IUPAC Name: D-alanyl-D-alanine compound with 2,2,2-trifluoroacetic acid (1:1)
InChIKey: AAYHSAYVLVQUQZ-VKKIDBQXSA-N
SMILES: C(C(O)=O)(F)(F)F.[C@H](NC([C@@H](C)N)=O)(C(O)=O)C
Biological Activity: D-Ala-D-Ala TFA is a bacterial endogenous metabolite. D-Ala-D-Ala TFA constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala TFA is catalyzed by D-Alanine-D-Alanine ligase[1][2][3].
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D-Ala-D-Ala TFA | D-Ala-D-Ala TFA is a bacterial endogenous metabolite. D-Ala-D-Ala TFA constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala TFA is catalyzed by D-Alanine-D-Alanine ligase. | |||||||||||||||||||||
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- [1]. Kitamura Y, et al. Structure of D-alanine-D-alanine ligase from Thermus thermophilus HB8: cumulative conformational change and enzyme-ligand interactions. Acta Crystallogr D Biol Crystallogr. 2009 Oct;65(Pt 10):1098-106. [Content Brief]
- [2]. Tytgat I, et al. DD-ligases as a potential target for antibiotics: past, present and future. Curr Med Chem. 2009;16(20):2566-80. [Content Brief]
- [3]. Trivedi RR, et al. Mechanical Genomic Studies Reveal the Role of d-Alanine Metabolism in Pseudomonas aeruginosa Cell Stiffness. mBio. 2018 Sep 11;9(5):e01340-18. [Content Brief]
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