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Cat. No.: HY-W015450A

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D-Ala-D-Ala TFA

(Synonyms: D-Alanyl-D-alanine TFA; H-D-Ala-D-Ala-OH TFA)

D-Ala-D-Ala TFA is a bacterial endogenous metabolite. D-Ala-D-Ala TFA constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala TFA is catalyzed by D-Alanine-D-Alanine ligase.

For research use only. We do not sell to patients.

CAS No.: 87155-77-9
Formula: C₈H₁₃F₃N₂O₅
Molecular Weight:274.20

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Please store the product under the recommended conditions in the Certificate of Analysis.

D-Ala-D-Ala TFA Chemical Structure

CAS No.: 87155-77-9

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Biological Activity
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Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vitro

D-Ala-D-Ala (15 mM) TFA shows a 30% decrease in the GRABS score for the dadA::Tn mutant^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 87155-77-9
Molecular Weight 274.20
Formula C₈H₁₃F₃N₂O₅
SMILES

C(C(O)=O)(F)(F)F.[C@H](NC([C@@H](C)N)=O)(C(O)=O)C
Synonyms

D-Alanyl-D-alanine TFA; H-D-Ala-D-Ala-OH TFA
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kitamura Y, et al. Structure of D-alanine-D-alanine ligase from Thermus thermophilus HB8: cumulative conformational change and enzyme-ligand interactions. Acta Crystallogr D Biol Crystallogr. 2009 Oct;65(Pt 10):1098-106. [Content Brief]

[2]. Tytgat I, et al. DD-ligases as a potential target for antibiotics: past, present and future. Curr Med Chem. 2009;16(20):2566-80. [Content Brief]

[3]. Trivedi RR, et al. Mechanical Genomic Studies Reveal the Role of d-Alanine Metabolism in Pseudomonas aeruginosa Cell Stiffness. mBio. 2018 Sep 11;9(5):e01340-18. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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D-Ala-D-Ala TFA

All Endogenous Metabolite Isoforms