87375-91-5
Chemical Structure
Dehydronitrosonisoldipine
- CAS No.: 87375-91-5
- Formula:C20H22N2O5
- Molecular Weight:370.40
IUPAC Name: 3-isobutyl 5-methyl 2,6-dimethyl-4-(2-nitrosophenyl)pyridine-3,5-dicarboxylate
InChIKey: UNMSLPIJQICBKA-UHFFFAOYSA-N
SMILES: O=C(C1=C(C2=CC=CC=C2N=O)C(C(OCC(C)C)=O)=C(C)N=C1C)OC
Biological Activity: Dehydronitrosonisoldipine, a derivative of Nisoldipine (HY-17402), is an irreversible and cell-permeant sterile alpha and TIR motif-containing 1 (SARM1) inhibitor. Dehydronitrosonisoldipine acts mainly by blocking SARM1 activation but not its enzymatic activities. Dehydronitrosonisoldipine inhibits SARM1 and axon degenration (AxD) by covalently modifying cysteines, also inhibits the Vincristine-activated cADPR production in neurons. Dehydronitrosonisoldipine can be used for researching neurodegenerative disorders[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dehydronitrosonisoldipine | 98.86% | Dehydronitrosonisoldipine, a derivative of Nisoldipine (HY-17402), is an irreversible and cell-permeant sterile alpha and TIR motif-containing 1 (SARM1) inhibitor. Dehydronitrosonisoldipine acts mainly by blocking SARM1 activation but not its enzymatic activities. Dehydronitrosonisoldipine inhibits SARM1 and axon degenration (AxD) by covalently modifying cysteines, also inhibits the Vincristine-activated cADPR production in neurons. Dehydronitrosonisoldipine can be used for researching neurodegenerative disorders. | ||||||||||||||||||||
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