87779-49-5
Chemical Structure
Bz-VGR-AMC
- CAS No.: 87779-49-5
- Formula:C30H37N7O6
- Molecular Weight:591.66
IUPAC Name: N-((S)-1-((2-(((S)-5-guanidino-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-3-methyl-1-oxobutan-2-yl)benzamide
InChIKey: PDUGCIODBWSTTA-NVQXNPDNSA-N
SMILES: CC(C(C(O1)=C2)=CC=C2NC([C@H](CCCNC(N)=N)NC(CNC([C@H](C(C)C)NC(C3=CC=CC=C3)=O)=O)=O)=O)=CC1=O
Biological Activity: Bz-VGR-AMC is a fluorescent substrate for the trypsin-like activity of the 20S proteasome. Bz-VGR-AMC can be used to measure the trypsin-like (β2) activity of the 20S proteasome (Ex/Em = 360/460 nm)[1][2].
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Bz-VGR-AMC | Bz-VGR-AMC is a fluorescent substrate for the trypsin-like activity of the 20S proteasome. Bz-VGR-AMC can be used to measure the trypsin-like (β2) activity of the 20S proteasome (Ex/Em = 360/460 nm). | |||||||||||||||||||||
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- [1]. Zhong YL, et al. Celastrol induce apoptosis of human multiple myeloma cells involving inhibition of proteasome activity. Eur J Pharmacol. 2019 Jun 15;853:184-192. [Content Brief]
- [2]. Jarome TJ, et al. CaMKII, but not protein kinase A, regulates Rpt6 phosphorylation and proteasome activity during the formation of long-term memories. Front Behav Neurosci. 2013 Aug 30;7:115. [Content Brief]
Keywords
