886-38-4
Chemical Structure
Diphenylcyclopropenone
Synonym(s): Diphencyprone
- CAS No.: 886-38-4
- Formula:C15H10O
- Molecular Weight:206.24
IUPAC Name: 2,3-diphenylcycloprop-2-en-1-one
InChIKey: HCIBTBXNLVOFER-UHFFFAOYSA-N
SMILES: O=C1C(C2=CC=CC=C2)=C1C3=CC=CC=C3
Biological Activity: Diphenylcyclopropenone (Diphencyprone) is a potent hapten acting as a topical immunomodulatory agent, which induces an allergic contact dermatitis. Diphenylcyclopropenone induces an increase of cell-surface thiols in cells of a human monocytic cell line, THP-1. Diphenylcyclopropenone acts on the autoreactive T-lymphocytes within the follicular milieu to induce Apoptosis. Diphenylcyclopropenone can be used for alopecia areata research[1][2][3][4].
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Diphenylcyclopropenone | 99.97% | Diphenylcyclopropenone (Diphencyprone) is a potent hapten acting as a topical immunomodulatory agent, which induces an allergic contact dermatitis. Diphenylcyclopropenone induces an increase of cell-surface thiols in cells of a human monocytic cell line, THP-1. Diphenylcyclopropenone acts on the autoreactive T-lymphocytes within the follicular milieu to induce Apoptosis. Diphenylcyclopropenone can be used for alopecia areata research. | ||||||||||||||||||||
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Diphenylcyclopropenone (Standard) | ≥98% | Diphenylcyclopropenone (Standard) is the analytical standard of Diphenylcyclopropenone. This product is intended for research and analytical applications. Diphenylcyclopropenone (Diphencyprone) is a topical immunomodulatory agent that can be used for alopecia areata research. | ||||||||||||||||||||
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References
- [1]. Yugang Gong, et al. Diphenylcyclopropenone plays an effective therapeutic role by up-regulating the TSLP/OX40L/IL-13 pathway in severe alopecia areata. Exp Dermatol. 2021 Feb;30(2):278-283. [Content Brief]
- [2]. Zekayi Kutlubay, et al. Assessment of treatment efficacy of diphenylcyclopropenone (DPCP) for alopecia areata. Turk J Med Sci. 2020 Dec 17;50(8):1817-1824. [Content Brief]
- [3]. Hirota M, et al. Changes of cell-surface thiols and intracellular signaling in human monocytic cell line THP-1 treated with diphenylcyclopropenone. J Toxicol Sci. 2010 Dec;35(6):871-9. [Content Brief]
- [4]. Svalgaard JD, et al. Systemic immunogenicity of para-Phenylenediamine and Diphenylcyclopropenone: two potent contact allergy-inducing haptens. Immunol Res. 2014 Jan;58(1):40-50. [Content Brief]
