90-49-3
Chemical Structure
Pheneturide
Synonym(s): Ethylphenacemide; M 551
- CAS. Nr.: 90-49-3
- Formula:C11H14N2O2
- Molecular Weight:206.25
IUPAC Name: N-carbamoyl-2-phenylbutanamide
InChIKey: AJOQSQHYDOFIOX-UHFFFAOYSA-N
SMILES: O=C(NC(N)=O)C(CC)C1=CC=CC=C1
Biological Activity: Pheneturide (Ethylphenacemide; M 551) is an orally active anticonvulsant. Pheneturide is a decarboxylation product of 5-ethyl-5-phenylbarbituric acid, with antiepileptic and central inhibitory effects. Pheneturide has protective effects against both MES tonic convulsions and Metrazol clonic convulsions. Pheneturide prolongs sedative-induced sleep, increases spontaneous locomotor activity, and inhibits fighting behavior. Pheneturide can be used in epilepsy-related research[1][2][3][4][5].
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Pheneturide | 99.20% | Pheneturide (Ethylphenacemide; M 551) is an orally active anticonvulsant. Pheneturide is a decarboxylation product of 5-ethyl-5-phenylbarbituric acid, with antiepileptic and central inhibitory effects. Pheneturide has protective effects against both MES tonic convulsions and Metrazol clonic convulsions. Pheneturide prolongs sedative-induced sleep, increases spontaneous locomotor activity, and inhibits fighting behavior. Pheneturide can be used in epilepsy-related research. | ||||||||||||||||||||
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Pheneturide (Standard) | 99.84% | Pheneturide (Ethylphenacemide; M 551) (Standard) is the analytical standard of Pheneturide (HY-111177). This product is intended for research and analytical applications. Pheneturide (Ethylphenacemide; M 551) is an orally active anticonvulsant. Pheneturide is a decarboxylation product of 5-ethyl-5-phenylbarbituric acid, with antiepileptic and central inhibitory effects. Pheneturide has protective effects against both MES tonic convulsions and Metrazol clonic convulsions. Pheneturide prolongs sedative-induced sleep, increases spontaneous locomotor activity, and inhibits fighting behavior. Pheneturide can be used in epilepsy-related research. | ||||||||||||||||||||
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References
- [1]. 中村圭二, et al. THE ANTICONVULSANT ACTIVITY OF ETHYL α-PHENYLBUTYROYL ALLOPHANATE (P-5257). The Japanese Journal of Pharmacology. 1963;13(3):259-73.
- [2]. Swinyard EA. Acetylurea derivatives. InAntiepileptic Drugs 1985 (pp. 601-610). Berlin, et al.
- [3]. Morton DJ. Effect of anticonvulsant drugs in vivo on rat pineal N‐acetyltransferase (EC 2.3. 1.5) and hydroxyindole‐O‐methyltransferase (EC 2.1. 1.4). Journal of pineal research. 1986 Apr;3(2):181-6.
- [4]. Mandel HG, et al. Interference of barbiturates with pyrimidine incorporation—II: Structural specificity of the inhibition of orotate uptake inBacillus cereus. Biochemical Pharmacology. 1970 Jun 1;19(6):1867-77.
- [5]. Masuda Y, et al. Differential antagonisms of anticonvulsants to various components of maximal seizures induced by electroshock or pentylenetetrazol in mice. Journal of pharmacobio-dynamics. 1980 Oct;3(10):526-31.
