9014-02-2
9014-02-2
Chemical Structure
Neocarzinostatin (solution)
Synonym(s): Zinostatin; Vinostatin
- CAS No.: 9014-02-2
- Formula:N/A
- Molecular Weight:N/A
SMILES: [Neocarzinostatin (solution)]
Biological Activity: Neocarzinostatin (solution), a potent DNA-damaging, anti-tumor antibiotic, recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin induces apoptosis. Neocarzinostatin has potential for EpCAM-positive cancers treatment [1][2].
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Neocarzinostatin (solution) | 99.9% | Neocarzinostatin (solution), a potent DNA-damaging, anti-tumor antibiotic, recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin induces apoptosis. Neocarzinostatin has potential for EpCAM-positive cancers treatment . | ||||||||||||||||||||
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References
- [1]. Athyala PK, et al. Probing the biophysical interaction between Neocarzinostatin toxin and EpCAM RNA aptamer. Biochem Biophys Res Commun. 2016 Jan 8;469(2):257-62. [Content Brief]
- [2]. Allen Taylor, et al. Ubiquitination capabilities in response to neocarzinostatin and H2O2 stress in cell lines from patients with ataxia-telangiectasia. Oncogene (2002) 21, 4363- 4373.
