906068-56-2
906068-56-2
Chemical Structure
Theralizumab
Synonym(s): TGN1412; TAB08
- CAS No.: 906068-56-2
- Formula:N/A
- Molecular Weight:(145.62 kDa)
SMILES: [Theralizumab]
Biological Activity: Theralizumab (TGN1412) is a humanized lgG4 superagonistic anti-CD28 monoclonal antibody that directly stimulates T cells. Theralizumab can cause cytokine release syndrome (CRS). Theralizumab can be used for the research of rheumatoid arthritis[1][2].
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Theralizumab | 99.46% | Theralizumab (TGN1412) is a humanized lgG4 superagonistic anti-CD28 monoclonal antibody that directly stimulates T cells. Theralizumab can cause cytokine release syndrome (CRS). Theralizumab can be used for the research of rheumatoid arthritis. | ||||||||||||||||||||
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References
- [1]. Thomas Hünig. The rise and fall of the CD28 superagonist TGN1412 and its return as TAB08: a personal account. FEBS J. 2016 Sep;283(18):3325-34. [Content Brief]
- [2]. Dmitry Tyrsin, et al. From TGN1412 to TAB08: the return of CD28 superagonist therapy to clinical development for the treatment of rheumatoid arthritis. Clin Exp Rheumatol. Jul-Aug 2016;34(4 Suppl 98):45-8. [Content Brief]
Keywords
