90686-13-8
Chemical Structure
Angustone A
Synonym(s): 2'-Hydroxylupalbigenin
- No. CAS: 90686-13-8
- Formula:C25H26O6
- Molecular Weight:422.47
InChIKey: KKFAKKIIFUFASS-UHFFFAOYSA-N
SMILES: O=C1C(C2=C(O)C(C/C=C(C)\C)=C(O)C=C2)=COC3=CC(O)=C(C/C=C(C)\C)C(O)=C13
Biological Activity: Angustone A (2'-Hydroxylupalbigenin) is a diisoprenylated isoflavone with insect feeding inhibitory activity and moderate antifungal activity. Angustone A can be converted into various phenolic metabolites by Aspergillus flavus through modification of the isoprenyl side chains at the C-6 and C-3' positions. Angustone A can be used in studies on antifungal properties of natural products, insect feeding behavior, fungal biotransformation, and anticancer activity[1][2][3].
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Angustone A | Angustone A (2'-Hydroxylupalbigenin) is a diisoprenylated isoflavone with insect feeding inhibitory activity and moderate antifungal activity. Angustone A can be converted into various phenolic metabolites by Aspergillus flavus through modification of the isoprenyl side chains at the C-6 and C-3' positions. Angustone A can be used in studies on antifungal properties of natural products, insect feeding behavior, fungal biotransformation, and anticancer activity. | |||||||||||||||||||||
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- [1]. Nakahara S, Tahara S, Mizutani J, Ingham JL. Transformation of the Diprenylated Isoflavone 2'-Hydroxylupalbigenin by Aspergillus flavus. Agricultural and Biological Chemistry. 1986;50(4):863-873.
- [2]. Lane GA, et al. Isoflavonoids as insect feeding deterrents and antifungal components from root ofLupinus angustifolius. Journal of chemical ecology. 1987 Apr;13(4):771-83.
- [3]. Fan H, Xuan J, Zhang K, Jiang J. Anticancer component identification from the extract of Dysosma versipellis and Glycyrrhiza uralensis based on support vector regression and mean impact value. Analytical Methods. 2018.
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