91-64-5
91-64-5
Chemical Structure
Coumarin
- CAS No.: 91-64-5
- Formula:C9H6O2
- Molecular Weight:146.15
IUPAC Name: 2H-chromen-2-one
InChIKey: ZYGHJZDHTFUPRJ-UHFFFAOYSA-N
SMILES: O=C1C=CC2=CC=CC=C2O1
Biological Activity: Coumarin is a potent and orally active anti-inflammatory agent. Coumarin shows an antinociceptive effect. Coumarin shows antibacterial, antifungal and anticancer activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Coumarin | 99.73% | Coumarin is a potent and orally active anti-inflammatory agent. Coumarin shows an antinociceptive effect. Coumarin shows antibacterial, antifungal and anticancer activity. | ||||||||||||||||||||
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Coumarin (Standard) | 99.96% | Coumarin (Standard) is the analytical standard of Coumarin. This product is intended for research and analytical applications. Coumarin is a potent and orally active anti-inflammatory agent. Coumarin shows an antinociceptive effect. Coumarin shows antibacterial, antifungal and anticancer activity. | ||||||||||||||||||||
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Coumarin-d6 | Coumarin-d6 is deuterated labeled Coumarin (HY-N0709). Coumarin is a potent and orally active anti-inflammatory agent. Coumarin shows an antinociceptive effect. Coumarin shows antibacterial, antifungal and anticancer activity. | |||||||||||||||||||||
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Coumarin-d4 | 99.93% | Coumarin-d4 is the deuterium labeled Coumarin. Coumarin is the primary bioactive ingredient in Radix Glehniae, named Beishashen in China, which possesses many pharmacological activities, including anticancer, anti-inflammation and antivirus activities. | ||||||||||||||||||||
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Thiocoumarin | Thiocoumarin is a carbonic anhydrase (CA) inhibitor, with Ki values of 0.047 μM, 0.042 μM, and 0.1 μM against hCA IX, mCA XIII, and hCA I, respectively; its Ki values against hCA IV, mCA XV, hCA II, hCA VA, hCA VB, hCA VI, hCA VII, hCA XII, and hCA XIV are 4.1, 4.8, 6.2, 8.4, 7.5, 8.8, 7.3, 8.7, and 7.4 μM, respectively. As a photocage molecule, Thiocoumarin undergoes photolysis upon illumination to release the caged molecule, and it exhibits red-shifted absorption properties and rapid photolysis kinetics. Thiocoumarin can be used in cancer-related research. | |||||||||||||||||||||
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8-Hydroxycoumarin | 99.63% | 8-Hydroxycoumarin is an intermediate in the microbial transformation of quinolone. | ||||||||||||||||||||
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4-Bromobiphenyl-d5 | ||||||||||||||||||||||
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Umbelliferone | 99.67% | Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats. | ||||||||||||||||||||
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Umbelliferone-d5 | 95.18% | Umbelliferone-d5 (7-Hydroxycoumarin-d5) is the deuterium labeled Umbelliferone (HY-N0573 ). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats. | ||||||||||||||||||||
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6-Methylcoumarin | 99.98% | 6-Methylcoumarin is a synthetic fragrance widely used in cosmetics. | ||||||||||||||||||||
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5-Hydroxycoumarin | 5-Hydroxycoumarin is a monohydroxycoumarin compound that occurs in the stems of Alyxia lucida, a plant of the genus Alyxia (Apocynaceae). | |||||||||||||||||||||
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7-Methylcoumarin (Standard) | ≥98% | 7-Methylcoumarin (Standard) is the analytical standard of 7-Methylcoumarin. This product is intended for research and analytical applications. 7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. 7-Methylcoumarin is a mechanism-based inhibitor for CYP2A6. 7-Methylcoumarin significantly decreases alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl4-induced liver damage, whilst restoring total protein (TP) and albumin (TA) levels in serum as well as preventing oxidative stress. 7-Methylcoumarin can decline mitotic activity of A. sativum promeristem. | ||||||||||||||||||||
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6-Hydroxycoumarin (Standard) | ≥98% | 6-Hydroxycoumarin (Standard) is the analytical standard of 6-Hydroxycoumarin (HY-N6656). This product is intended for research and analytical applications. 6-Hydroxycoumarin is a plant-derived secondary metabolite of the coumarin class, possessing insecticidal, antitumor, and other biological activities. 6-Hydroxycoumarin targets the midgut tissue of the red imported fire ant (Solenopsis invicta), inhibits CYP450, induces elevated activities of GST, CarE, and SOD, disrupts mitochondrial ultrastructure, triggers apoptosis, and also impairs insect neuromuscular behavior. 6-Hydroxycoumarin exhibits photoallergic properties and serves as an intermediate for the synthesis of isoxazolyl and triazolyl derivatives. 6-Hydroxycoumarin is applicable to research related to red imported fire ant control. | ||||||||||||||||||||
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6-Bromocoumarin | 6-Bromocoumarin (compound 34) is a potential anti-bacterial agent, with no inhibition against 17β-HSD1. 6-Bromocoumarin exhibtis affinity for α and β estrogen receptors. | |||||||||||||||||||||
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1,4-Diiodobenzene-d4 | 1,4-Diiodobenzene-d4 is the deuterium labeled 1,4-Diiodobenzene (HY-W007412). | |||||||||||||||||||||
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7-Aminocoumarin | 7-Aminocoumarin is highly fluorescent, acts as an optical brightener and fluorescent probe. | |||||||||||||||||||||
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Naphthalene-1,5-diamine-d6 | Naphthalene-1,5-diamine-d6 (1,5-Naphthylene-diamine-d6) is the deuterium labeled Naphthalene-1,5-diamine (HY-W012566). | |||||||||||||||||||||
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Indole-d4 | Indole-d4 is the deuterium labeled Indole (HY-W001132). Indole is an aromatic, heterocyclic, organic compound which widely distributed in the natural environment and can be produced by a variety of bacteria. Indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence as an intercellular signal molecule. | |||||||||||||||||||||
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Umbelliferone-13C6 | Umbelliferone-13C6 (7-Hydroxycoumarin-13C6) is the 13C-labeled Umbelliferone (HY-N0573). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats. | |||||||||||||||||||||
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4-Hydroxy biphenyl-d5 | 4-Hydroxy biphenyl-d5 is deuterium labeled [1,1'-Biphenyl]-4-ol. | |||||||||||||||||||||
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1,4-Dichlorobenzene-d4 | 99.0% | 1,4-Dichlorobenzene-d4 is the deuterium labeled 1,4-Dichlorobenzene. 1,4-Dichlorobenzene is a non-genotoxic, orally active mitogenic/tumor-promoting carcinogen that is also widely used as a dye, resin intermediate, and deodorant, moth repellent/insecticide. 1,4-Dichlorobenzene induces liver tumors in mice and promotes the growth of spontaneous precancerous lesions, but shows no liver tumor-inducing activity in F344 rats. 1,4-Dichlorobenzene increases the levels of white blood cell count, serum alanine aminotransferase and blood urea nitrogen in occupationally exposed populations. 1,4-Dichlorobenzene is metabolized to 2,5-dichlorophenol and excreted in urine, and this metabolite can serve as a biomarker for 1,4-Dichlorobenzene exposure. Due to its specific hepatotoxic characteristics, 1,4-Dichlorobenzene is applicable to liver cancer-related research. | ||||||||||||||||||||
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References
- [1]. Park SH, et al. Antinociceptive profiles and mechanisms of orally administered coumarin in mice. Biol Pharm Bull. 2013;36(6):925-30. [Content Brief]
- [2]. enugopala KN, et al. Review on natural coumarin lead compounds for their pharmacological activity. Biomed Res Int. 2013;2013:963248. [Content Brief]
