92121-68-1
Chemical Structure
Obafluorin
- CAS No.: 92121-68-1
- Formula:C17H14N2O7
- Molecular Weight:358.30
IUPAC Name: 2,3-dihydroxy-N-((2R,3S)-2-(4-nitrobenzyl)-4-oxooxetan-3-yl)benzamide
InChIKey: AINNQKIVZOTQBB-KGLIPLIRSA-N
SMILES: O=C(C(C=CC=C1O)=C1O)N[C@H](C2=O)[C@H](O2)CC(C=C3)=CC=C3[N+]([O-])=O
Biological Activity: Obafluorin is a β-lactone antibiotic. Obafluorin inhibits threonyl-tRNA synthetase (PfThrRS) with an IC50 of 4.3 nM. Obafluorin inhibits the aminoacylation activity of EcThrRS and ObaO. Obafluorin exhibits Fe3+-enhanced antibacterial activity. Obafluorin can be used in studies related to infections caused by bacterial and parasites such as Plasmodium[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Obafluorin | 99.9% | Obafluorin is a β-lactone antibiotic. Obafluorin inhibits threonyl-tRNA synthetase (PfThrRS) with an IC50 of 4.3 nM. Obafluorin inhibits the aminoacylation activity of EcThrRS and ObaO. Obafluorin exhibits Fe3+-enhanced antibacterial activity. Obafluorin can be used in studies related to infections caused by bacterial and parasites such as Plasmodium. | ||||||||||||||||||||
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- [1]. Scott TA, et al. Immunity-Guided Identification of Threonyl-tRNA Synthetase as the Molecular Target of Obafluorin, a β-Lactone Antibiotic. ACS Chem Biol. 2019;14(12):2663-2671. [Content Brief]
- [2]. Batey SFD, et al. The catechol moiety of obafluorin is essential for antibacterial activity. RSC Chem Biol. 2023;4(11):926-941. Published 2023 Aug 21. [Content Brief]
Keywords
