937-34-8
Chemical Structure
Phenyl sulfate
Synonym(s): Phenyl hydrogen sulfate
- CAS No.: 937-34-8
- Formula:C6H6O4S
- Molecular Weight:174.17
InChIKey: CTYRPMDGLDAWRQ-UHFFFAOYSA-N
SMILES: O=S(OC1=CC=CC=C1)(O)=O
Biological Activity: Phenyl sulfate (Phenyl hydrogen sulfate) is an orally active gut microbiota-derived metabolite. Phenyl sulfate undergoes hepatic sulfation via SULT1A1. Phenyl sulfate induces podocyte injury, albuminuria, renal pro-inflammatory and pro-fibrotic effects, cytotoxicity, glutathione depletion, mitochondrial dysfunction, and sensitizes renal tubular cells to oxidative stress. Phenyl sulfate can be used in research on diabetic nephropathy[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Phenyl sulfate | 99.47% | Phenyl sulfate (Phenyl hydrogen sulfate) is an orally active gut microbiota-derived metabolite. Phenyl sulfate undergoes hepatic sulfation via SULT1A1. Phenyl sulfate induces podocyte injury, albuminuria, renal pro-inflammatory and pro-fibrotic effects, cytotoxicity, glutathione depletion, mitochondrial dysfunction, and sensitizes renal tubular cells to oxidative stress. Phenyl sulfate can be used in research on diabetic nephropathy. | ||||||||||||||||||||
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Phenyl sulfate (Standard) | 98.31% | Phenyl sulfate (Standard) (Phenyl hydrogen sulfate (Standard)) is the analytical standard of Phenyl sulfate (HY-128442). This product is intended for research and analytical applications. Phenyl sulfate (Phenyl hydrogen sulfate) is an orally active gut microbiota-derived metabolite. Phenyl sulfate undergoes hepatic sulfation via SULT1A1. Phenyl sulfate induces podocyte injury, albuminuria, renal pro-inflammatory and pro-fibrotic effects, cytotoxicity, glutathione depletion, mitochondrial dysfunction, and sensitizes renal tubular cells to oxidative stress. Phenyl sulfate can be used in research on diabetic nephropathy. | ||||||||||||||||||||
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Phenylsulfate-d5 sodium | Phenylsulfate-d5 (sodium) is the deuterium labeled Phenylsulfate sodium. | |||||||||||||||||||||
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References
- [1]. Kikuchi K, et al. Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease. Nature communications. 2019 Apr 23;10(1):1835. [Content Brief]
- [2]. Bai FY, et al. Unlocking the Hidden Source of Phenyl Sulfate and Role in the Atmosphere: Alkali-Catalyzed Barrierless Formation Mechanism and Impact on Aerosol Nucleation. Environmental science & technology. 2025 Nov 04;59(43):23410-23421.
- [3]. Lin TY, et al. An oral tyrosine challenge test for functional phenotyping of microbiota-derived phenyl sulfate production. npj metabolic health and disease. 2026 Jun 02;4(1):20.
- [4]. Edamatsu T, et al. Phenyl sulfate, indoxyl sulfate and p-cresyl sulfate decrease glutathione level to render cells vulnerable to oxidative stress in renal tubular cells. PloS one. 2018;13(2):e0193342.
