938-55-6
Chemical Structure
6-(Dimethylamino)purine
Synonym(s): 6-Dimethylaminopurine; 6-DMAP
- CAS No.: 938-55-6
- Formula:C7H9N5
- Molecular Weight:163.18
IUPAC Name: N,N-dimethyl-9H-purin-6-amine
InChIKey: BVIAOQMSVZHOJM-UHFFFAOYSA-N
SMILES: CN(C)C1=C2NC=NC2=NC=N1
Biological Activity: 6-(Dimethylamino) purine (6-Dimethylaminopurine) is a serine threonine protein kinase inhibitor. 6-(Dimethylamino) purine can inhibit prolactin induced expression of lactoprotein genes in rabbit mammary gland cells. 6-(Dimethylamino) purine can affect the maturation of mammalian oocytes. 6-(Dimethylamino) purine can lead to downregulation of genes related to cell proliferation and cell cycle progression, such as proliferating cell nuclear antigen, insulin-like gene 1, and serine protease inhibitor 2 genes, and induce apoptosis in lymphoma cells (apoptosis)[1][3][5].
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6-(Dimethylamino)purine | 99.90% | 6-(Dimethylamino) purine (6-Dimethylaminopurine) is a serine threonine protein kinase inhibitor. 6-(Dimethylamino) purine can inhibit prolactin induced expression of lactoprotein genes in rabbit mammary gland cells. 6-(Dimethylamino) purine can affect the maturation of mammalian oocytes. 6-(Dimethylamino) purine can lead to downregulation of genes related to cell proliferation and cell cycle progression, such as proliferating cell nuclear antigen, insulin-like gene 1, and serine protease inhibitor 2 genes, and induce apoptosis in lymphoma cells (apoptosis). | ||||||||||||||||||||
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6-(Dimethylamino)purine (Standard) | ≥98% | 6-(Dimethylamino) purine (6-Dimethylaminopurine) is a serine threonine protein kinase inhibitor. 6-(Dimethylamino) purine can inhibit prolactin induced expression of lactoprotein genes in rabbit mammary gland cells. 6-(Dimethylamino) purine can affect the maturation of mammalian oocytes. 6-(Dimethylamino) purine can lead to downregulation of genes related to cell proliferation and cell cycle progression, such as proliferating cell nuclear antigen, insulin-like gene 1, and serine protease inhibitor 2 genes, and induce apoptosis in lymphoma cells (apoptosis). | ||||||||||||||||||||
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Similarity Score 0.84
HY-116887N6-Methyladenine -
Similarity Score 0.81
HY-B0152S1Adenine-13C -
Similarity Score 0.79
HY-W424876N-(7H-Purin-6-yl)acetamide -
Similarity Score 0.79
HY-Y02476-Chloropurine -
Similarity Score 0.76
HY-W097453R6-(Methylthio)purine (Standard) -
Similarity Score 0.76
HY-B0152Adenine -
Similarity Score 0.75
HY-B0152ARAdenine hydrochloride (Standard) -
Similarity Score 0.75
HY-W712567Adenine-15N5 hydrochloride -
Similarity Score 0.74
HY-13677S16-Mercaptopurine-13C2,15N -
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References
- [1]. Szöllösi MS, et al. Inhibition of protein kinases by 6-dimethylaminopurine accelerates the transition to interphase in activated mouse oocytes. J Cell Sci. 1993 Mar;104 ( Pt 3):861-72. [Content Brief]
- [3]. Bayat-Sarmadi M, et al. 6-Dimethyl amino purine and 2-amino purine inhibit the induction of expression of milk protein genes by prolactin. Biosci Rep. 1992 Jun;12(3):189-97. [Content Brief]
- [5]. Nakashima M, et al. Apoptosis induced by an alkylated purine, 6-dimethylaminopurine, and changes in gene expression in human lymphoma U937 cells. Anticancer Res. 2008 Mar-Apr;28(2A):609-20. [Content Brief]
