949467-71-4
949467-71-4
Chemical Structure
hENT4-IN-1
- CAS No.: 949467-71-4
- Formula:C26H48N8O2
- Molecular Weight:504.71
IUPAC Name: 2,2'-((4,8-bis(diisobutylamino)pyrimido[5,4-d]pyrimidine-2,6-diyl)bis(azanediyl))bis(ethan-1-ol)
InChIKey: KIZLZYHFIWWKIL-UHFFFAOYSA-N
SMILES: CC(C)CN(C1=NC(NCCO)=NC2=C1N=C(NCCO)N=C2N(CC(C)C)CC(C)C)CC(C)C
Biological Activity: hENT4-IN-1 is a potent and selective human ENT4 (equilibrative nucleoside transporter 4) inhibitor with an IC50 of 74.4 nM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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hENT4-IN-1 | 99.94% | hENT4-IN-1 is a potent and selective human ENT4 (equilibrative nucleoside transporter 4) inhibitor with an IC50 of 74.4 nM. | ||||||||||||||||||||
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hENT4-IN-1 (Standard) | ≥98% | hENT4-IN-1 (Standard) is the analytical standard of hENT4-IN-1 (HY-110165). This product is intended for research and analytical applications. hENT4-IN-1 is a potent and selective human ENT4 (equilibrative nucleoside transporter 4) inhibitor with an IC50 of 74.4 nM. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.58
HY-119291RA642 -
Similarity Score 0.53
HY-B0312Dipyridamole -
Similarity Score 0.52
HY-106618Mopidamol -
Similarity Score 0.51
HY-1101048MDP -
Similarity Score 0.46
HY-111093Protein kinase inhibitor 8 -
Similarity Score 0.43
HY-122746E67-2 -
Similarity Score 0.41
HY-W740060Dipyridamole Mono-O-β-D-glucuronide -
Similarity Score 0.41
HY-B0312S1Dipyridamole-d16 -
Similarity Score 0.40
HY-B0312SDipyridamole-d20 -
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References
- [1]. Wang C, et al. Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4). Biochem Pharmacol. 2013 Dec 1;86(11):1531-40. [Content Brief]
