95520-87-9
Chemical Structure
PA-082
- CAS No.: 95520-87-9
- Formula:C33H38N2O5
- Molecular Weight:542.68
IUPAC Name: 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-4-((4-(2-methoxyphenyl)piperidin-1-yl)methyl)isoquinoline
InChIKey: DJEGOJNHRNRMHS-UHFFFAOYSA-N
SMILES: N=1C=C(C=2C=C(OC)C(OC)=CC2C1CC3=CC=C(OC)C(OC)=C3)CN4CCC(C=5C=CC=CC5OC)CC4
Biological Activity: PA-082 is a selective PPAR-γ modulator that functions as a partial agonist. PA-082 causes partial recruitment of SRC1, TIF2, SRC3 and full recruitment of PGC1-α to PPAR-γ ligand-binding domain. PA-082 prevents triglyceride accumulation during de novo adipogenesis and antagonizes Rosiglitazone (HY-17386)-induced lipid accumulation. PA-082 potentiates insulin-stimulated glucose uptake in adipocytes and protects against TNFα-induced insulin resistance. PA-082 can be used for the research of type 2 diabetes[1].
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PA-082 | PA-082 is a selective PPAR-γ modulator that functions as a partial agonist. PA-082 causes partial recruitment of SRC1, TIF2, SRC3 and full recruitment of PGC1-α to PPAR-γ ligand-binding domain. PA-082 prevents triglyceride accumulation during de novo adipogenesis and antagonizes Rosiglitazone (HY-17386)-induced lipid accumulation. PA-082 potentiates insulin-stimulated glucose uptake in adipocytes and protects against TNFα-induced insulin resistance. PA-082 can be used for the research of type 2 diabetes. | |||||||||||||||||||||
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Keywords
