958843-91-9
Chemical Structure
CMLD-2
- CAS No.: 958843-91-9
- Formula:C31H31NO6
- Molecular Weight:513.58
IUPAC Name: 5,7-dimethoxy-8-(1-(4-methoxyphenyl)-3-oxo-3-(pyrrolidin-1-yl)propyl)-4-phenyl-2H-chromen-2-one
InChIKey: PROGRNRRJJYCNX-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=CC=C2)C3=C(OC)C=C(OC)C(C(C4=CC=C(OC)C=C4)CC(N5CCCC5)=O)=C3O1
Biological Activity: CMLD-2, an inhibitor of HuR-ARE interaction, competitively binds HuR protein disrupting its interaction with adenine-uridine rich elements (ARE)-containing mRNAs (Ki=350 nM). CMLD-2 induces apoptosis exhibits antitumor activity in different cancer cells as colon, pancreatic, thyroid and lung cancer cell lines. Hu antigen R (HuR) is an RNA binding protein, can regulate target mRNAs stability and translation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CMLD-2 | 98.66% | CMLD-2, an inhibitor of HuR-ARE interaction, competitively binds HuR protein disrupting its interaction with adenine-uridine rich elements (ARE)-containing mRNAs (Ki=350 nM). CMLD-2 induces apoptosis exhibits antitumor activity in different cancer cells as colon, pancreatic, thyroid and lung cancer cell lines. Hu antigen R (HuR) is an RNA binding protein, can regulate target mRNAs stability and translation. | ||||||||||||||||||||
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Similarity Score 0.56
HY-148765CLK8 -
Similarity Score 0.54
HY-180946AChE-IN-105 -
Similarity Score 0.53
HY-N19836iso-Pedilanthocoumarin B -
Similarity Score 0.51
HY-N10304Isodispar B -
Similarity Score 0.50
HY-N19721Brasimarin B -
Similarity Score 0.50
HY-122594BNS-22 -
Similarity Score 0.50
HY-N10443Mammea A/BA -
Similarity Score 0.49
HY-N3294Mesuol -
Similarity Score 0.49
HY-N13645Inophyllum E -
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References
- [1]. Wu X, et, al. Identification and validation of novel small molecule disruptors of HuR-mRNA interaction. ACS Chem Biol. 2015 Jun 19;10(6):1476-84. [Content Brief]
- [2]. Allegri , et, al. The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells. Sci Rep. 2019 May 14;9(1):7374. [Content Brief]
