96748-86-6
96748-86-6
Chemical Structure
Deoxynyboquinone
- CAS No.: 96748-86-6
- Formula:C15H12N2O4
- Molecular Weight:284.27
IUPAC Name: 1,4,6-trimethylpyrido[3,2-g]quinoline-2,5,8,10(1H,9H)-tetraone
InChIKey: KJYPAIRTXRKKHG-UHFFFAOYSA-N
SMILES: O=C1N(C)C2=C(C(C(C(C)=CC(N3)=O)=C3C2=O)=O)C(C)=C1
Biological Activity: Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone kills cancer cells through oxidative stress and reactive oxygen species (ROS) formation[1][2][3].
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Deoxynyboquinone | 99.21% | Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone kills cancer cells through oxidative stress and reactive oxygen species (ROS) formation. | ||||||||||||||||||||
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Deoxynyboquinone (Standard) | ≥98% | Deoxynyboquinone (Standard) is the analytical standard of Deoxynyboquinone (HY-108992). This product is intended for research and analytical applications. Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone Kills cancer cells through oxidative stress and reactive oxygen species (ROS) formation. | ||||||||||||||||||||
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References
- [1]. Elizabeth I Parkinson, et al. Deoxynyboquinones as NQO1-Activated Cancer Therapeutics. Acc Chem Res. 2015 Oct 20;48(10):2715-23. [Content Brief]
- [2]. Joseph S Bair, et al. Chemistry and biology of deoxynyboquinone, a potent inducer of cancer cell death. J Am Chem Soc. 2010 Apr 21;132(15):5469-78. [Content Brief]
- [3]. Tudor G, et,al. Cytotoxicity and apoptosis of benzoquinones: redox cycling, cytochrome c release, and BAD protein expression. Biochem Pharmacol. 2003;65(7):1061-1075. [Content Brief]
