97207-47-1
97207-47-1
Chemical Structure
Meisoindigo
Synonym(s): Dian III; N-Methylisoindigotin; Natura-α
- CAS No.: 97207-47-1
- Formula:C17H12N2O2
- Molecular Weight:276.29
IUPAC Name: (E)-1-methyl-[3,3'-biindolinylidene]-2,2'-dione
InChIKey: QNOCRUSVMMAKSC-CCEZHUSRSA-N
SMILES: O=C1N(C)C2=C(C=CC=C2)/C1=C3C(NC4=C\3C=CC=C4)=O
Biological Activity: Meisoindigo (Dian III), a derivative of Indirubin (HY-N0117), halts the cell cycle at the G0/G1 phase and induces apoptosis in primary acute myeloid leukemia (AML) cells. Meisoindigo exhibits high antitumor activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Meisoindigo | 99.91% | Meisoindigo (Dian III), a derivative of Indirubin (HY-N0117), halts the cell cycle at the G0/G1 phase and induces apoptosis in primary acute myeloid leukemia (AML) cells. Meisoindigo exhibits high antitumor activity. | ||||||||||||||||||||
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Meisoindigo (Standard) | ≥98% | Meisoindigo (Standard) is the analytical standard of Meisoindigo. This product is intended for research and analytical applications. Meisoindigo (Dian III), a derivative of Indirubin (HY-N0117), halts the cell cycle at the G0/G1 phase and induces apoptosis in primary acute myeloid leukemia (AML) cells. Meisoindigo exhibits high antitumor activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.80
HY-185575ATM ligand-1 -
Similarity Score 0.75
HY-107869RIsoindigo (Standard) -
Similarity Score 0.64
HY-N0117Indirubin -
Similarity Score 0.64
HY-N0117AR(Z)-Indirubin (Standard) -
Similarity Score 0.60
HY-139254Indirubin-3′-oxime -
Similarity Score 0.60
HY-19807Indirubin-3'-monoxime -
Similarity Score 0.58
![6,6'-Dibromo-[3,3'-biindolinylidene]-2,2'-dione Chemical Structure](//file.medchemexpress.com/product_pic/hy-w124405.gif)
HY-W1244056,6'-Dibromo-[3,3'-biindolinylidene]-2,2'-dione -
Similarity Score 0.57
HY-21292SU5214 -
Similarity Score 0.57
HY-103221MeBIO -
Explore the MedChemAI to find more analogs
![6,6'-Dibromo-[3,3'-biindolinylidene]-2,2'-dione Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w124405.gif)
References
- [1]. Lee CC, et al. Meisoindigo is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia. Leuk Lymphoma. 2010 May;51(5):897-905. [Content Brief]
- [2]. Yingze Ye, et al. Meisoindigo Protects Against Focal Cerebral Ischemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Regulating Microglia/Macrophage Polarization via TLR4/NF-κB Signaling Pathway. Front Cell Neurosci. 2019 Dec 16;13:553. [Content Brief]
