99-18-3
99-18-3
Chemical Structure
Prunasin
- CAS No.: 99-18-3
- Formula:C14H17NO6
- Molecular Weight:295.29
IUPAC Name: (R)-2-phenyl-2-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)acetonitrile
InChIKey: ZKSZEJFBGODIJW-GMDXDWKASA-N
SMILES: N#C[C@@H](C1=CC=CC=C1)O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO
Biological Activity: Prunasin is an orally active cyanogenic glucoside and the main metabolite of Amygdalin (HY-N0190). Prunasin can specifically inhibit rat DNA polymerase β (IC50: 98 μM). Prunasin has anti-inflammatory and anti-fibrotic activities. Prunasin can be used in the research of diseases such as liver fibrosis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Prunasin | 99.56% | Prunasin is an orally active cyanogenic glucoside and the main metabolite of Amygdalin (HY-N0190). Prunasin can specifically inhibit rat DNA polymerase β (IC50: 98 μM). Prunasin has anti-inflammatory and anti-fibrotic activities. Prunasin can be used in the research of diseases such as liver fibrosis. | ||||||||||||||||||||
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Laetrile | Laetrile (NSC103055) is a natural product. | |||||||||||||||||||||
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Neoamygdalin | 99.59% | Neoamygdalin is a compound identified in the different processed bitter almonds. Neoamygdalin has the potential for the research of cough and asthma. | ||||||||||||||||||||
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Amygdalin (Standard) | ≥98% | Amygdalin (Standard) is the analytical standard of Amygdalin. This product is intended for research and analytical applications. Amygdalin is a plant glucoside isolated from the stones of rosaceous fruits, such as apricots, peaches, almond, cherries, and plums. | ||||||||||||||||||||
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Taxiphyllin | 98% | Taxiphyllin (2R-Taxiphyllin) is a plant cyanogenic glycoside, which exhibits inhibitory activity for tyrosinase. Taxiphyllin exhibits cytotoxicity in BRL-3A cellls with an IC50 of 18.75 μm and antimicrobial activities against Staphylococcus aureus with an EC50 of 0.96 μM. |
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Zierin | Zierin can be found in Xeranthemum annuum L. Zierin has potential anti-inflammatory and antioxidant activities. | |||||||||||||||||||||
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Prunasinamide | Prunasinamide is a catabolite of Prunasin (HY-N1548) and can be found in senescent leaves of Prunus laurocerasus. Prunasinamide can be generated from Prunasin via the Radziszewski reaction. | |||||||||||||||||||||
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Dhurrin | 98.67% | Dhurrin is a cyanogenic glucoside isolated from Sorghum. | ||||||||||||||||||||
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Benzyl β-D-glucopyranoside | 98.48% | Benzyl β-D-glucopyranoside is a benzyl glycoside and also a synthetic intermediate. Benzyl β-D-glucopyranoside can serve as a substrate and interact with a series of enzymes. | ||||||||||||||||||||
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Phenylmethyl α-D-mannopyranoside | Phenylmethyl α-D-mannopyranoside is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology. | |||||||||||||||||||||
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Periplanetin | 97.38% | Periplanetin is a peptide of the insect lipomotor hormone family (AKH family) that can be isolated from the secretion of the cervical organ of Periplaneta americana L. and Blatta orientalis L. The periplanetin peptide has potential analgesic activity and lowers the threshold of tonic seizures. | ||||||||||||||||||||
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References
- [1]. Mizushina Y, et al. The cyanogenic glucoside, prunasin (D-mandelonitrile-beta-D-glucoside), is a novel inhibitor of DNA polymerase beta. J Biochem. 1999;126(2):430-436. [Content Brief]
- [2]. Zhang C, et al. Pharmacokinetics and anti-liver fibrosis characteristics of amygdalin: Key role of the deglycosylated metabolite prunasin. Phytomedicine. 2022 May;99:154018. [Content Brief]
