Ceronapril (Synonyms: Ceranapril; SQ 29852)

Cat. No.: HY-106816: FAQs
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Ceronapril (SQ 29852) is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with an IC₅₀ of 36 nM.

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Ceronapril Chemical Structure

CAS No. : 111223-26-8

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Description

Ceronapril (SQ 29852) is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with an IC₅₀ of 36 nM^[1].

IC₅₀ & Target

IC50: 36 nM (ACE)^[1]

In Vivo

Ceronapril (SQ 29852) inhibits ACE in male SD rats with ED₅₀s of 0.063 μM/kg and 0.53 μM/kg by IV and PO, respectively^[1].
Ceronapril (100 mg/kg; p.o.; single dose or twice daily for 3 days) blocks ACE in peripheral sites in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats^[2]
Dosage:	100 mg/kg
Administration:	PO, twice daily for 3 days or single daily dose
Result:	Showed clear inhibition of ACE in the 2 circumventricular organs-the subfornical organ and the lamina terminals-but no change in other regions of the brain after chronic treatment. Inhibited ACE in plasma, kidney and lung rapidly (3 hr) after a single administration. Did not inhibit ACE in structures of the brain within the blood-brain barrier, such as the caudate-putamen, choroid plexus, globus pallidus, supraoptic nucleus and paraventricular nucleus of the hypothalamus.

Molecular Weight

440.47

Formula

C₂₁H₃₃N₂O₆P

CAS No.

111223-26-8

SMILES

O=P(CCCCC1=CC=CC=C1)(O)O[C@@H](CCCCN)C(N2[C@@H](CCC2)C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Karanewsky D S, et al. (Phosphinyloxy) acyl amino acid inhibitors of angiotensin converting enzyme (ACE). 1. Discovery of (S)-1-[6-amino-2-[[hydroxy (4-phenylbutyl) phosphinyl] oxy]-1-oxohexyl]-L-proline, a novel orally active inhibitor of ACE. Journal of medicinal chemistry, 1988, 31(1): 204-212.

[2]. Chen BZ, et al. Effect of acute and chronic administration of ceronapril on angiotensin converting enzyme in plasma, kidney, lung, brain regions and cerebrospinal fluid of rats. Neuropharmacology. 1992 Sep;31(9):929-35. [Content Brief]

Ceronapril Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ceronapril111223-26-8Ceranapril SQ 29852SQ29852SQ 29852SQ-29852Angiotensin-converting Enzyme (ACE)SD ratskidneylungorally activeInhibitorinhibitorinhibit

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