Art. -Nr.: HY-80002

BMX-IN-1

(Synonyms: BMX kinase inhibitor)

7 Cited Publications

Kundenbewertung

Based on 7 publication(s) in Google Scholar

BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys⁴⁹⁶ in the BMX ATP binding domain with an IC₅₀ of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC₅₀ value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.

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Reinheit: 98.90%
CAS. Nr.: 1431525-23-3
Formel: C₂₉H₂₄N₄O₄S
Molecular Weight:524.59

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

BMX-IN-1 Chemical Structure

CAS. Nr.: 1431525-23-3

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Use of MCE Products

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (7)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Protokoll
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 8 nM (BMX), 10.4 nM (BTK)

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	GI₅₀	>10 μM Compound: Chemical Probe: BMX-IN-1, QL-XII-61	Cytotoxicity against mouse BaF3 cells assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay Cytotoxicity against mouse BaF3 cells assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay	[PMID: 23594111]
BaF3	GI₅₀	0.025 μM Compound: Chemical Probe: BMX-IN-1, QL-XII-61	Antiproliferative activity against mouse BaF3 cells expressing TEL-fused BMX assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay Antiproliferative activity against mouse BaF3 cells expressing TEL-fused BMX assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay	[PMID: 23594111]
BaF3	GI₅₀	3.64 μM Compound: Chemical Probe: BMX-IN-1, QL-XII-61	Antiproliferative activity against mouse BaF3 cells expressing TEL-fused BLK assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay Antiproliferative activity against mouse BaF3 cells expressing TEL-fused BLK assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay	[PMID: 23594111]
BaF3	GI₅₀	4.92 μM Compound: Chemical Probe: BMX-IN-1, QL-XII-61	Antiproliferative activity against mouse BaF3 cells expressing TEL-fused JAK1 assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay Antiproliferative activity against mouse BaF3 cells expressing TEL-fused JAK1 assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay	[PMID: 23594111]
BaF3	GI₅₀	5.83 μM Compound: Chemical Probe: BMX-IN-1, QL-XII-61	Antiproliferative activity against mouse BaF3 cells expressing TEL-fused JAK2 assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay Antiproliferative activity against mouse BaF3 cells expressing TEL-fused JAK2 assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay	[PMID: 23594111]
BaF3	GI₅₀	6.09 μM Compound: Chemical Probe: BMX-IN-1, QL-XII-61	Antiproliferative activity against mouse BaF3 cells expressing TEL-fused TYK2 E9757D mutant assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay Antiproliferative activity against mouse BaF3 cells expressing TEL-fused TYK2 E9757D mutant assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay	[PMID: 23594111]
BaF3	GI₅₀	7.98 μM Compound: Chemical Probe: BMX-IN-1, QL-XII-61	Antiproliferative activity against mouse BaF3 cells expressing TEL-fused JAK3 assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay Antiproliferative activity against mouse BaF3 cells expressing TEL-fused JAK3 assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay	[PMID: 23594111]
BaF3	IC₅₀	>10 μM Compound: Chemical Probe: BMX-IN-1, QL-XII-61	Antiproliferative activity against mouse BaF3 cells expressing TEL-fused BMX Cys496Ser assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay Antiproliferative activity against mouse BaF3 cells expressing TEL-fused BMX Cys496Ser assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay	[PMID: 23594111]
BaF3	IC₅₀	25 nM Compound: BMX-IN-1	Antiproliferative activity against TEL-BMX transformed mouse BaF3 cells assessed as inhibition of cell proliferation Antiproliferative activity against TEL-BMX transformed mouse BaF3 cells assessed as inhibition of cell proliferation	[PMID: 37437350]
BaF3	IC₅₀	569 nM Compound: Chemical Probe: BMX-IN-1, QL-XII-61	Antiproliferative activity against mouse BaF3 cells expressing TEL-fused BMX assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay Antiproliferative activity against mouse BaF3 cells expressing TEL-fused BMX assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay	[PMID: 23594111]
DU-145	GI₅₀	4.38 μM Compound: Chemical Probe: BMX-IN-1, QL-XII-61	Antiproliferative activity against human DU-145 cells assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay Antiproliferative activity against human DU-145 cells assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay	[PMID: 23594111]
LNCaP C4-2	GI₅₀	>10 μM Compound: Chemical Probe: BMX-IN-1, QL-XII-61	Antiproliferative activity against human C4-2 cells assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay Antiproliferative activity against human C4-2 cells assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay	[PMID: 23594111]
PC-3	GI₅₀	5.37 μM Compound: Chemical Probe: BMX-IN-1, QL-XII-61	Antiproliferative activity against human PC-3 cells assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay Antiproliferative activity against human PC-3 cells assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay	[PMID: 23594111]
VCaP	GI₅₀	2.46 μM Compound: Chemical Probe: BMX-IN-1, QL-XII-61	Antiproliferative activity against human VCaP cells assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay Antiproliferative activity against human VCaP cells assessed growth inhibition incubated for 2 to 5 days by CellTiter-Glo assay	[PMID: 23594111]

In Vitro

BMX-IN-1 inhibits the proliferation of Tel-BMX-transformed Ba/F3 cells and RV-1 cells with IC₅₀s of 25 nM and 2.53 μM. BMX-IN-1 exhibits remarkable selectivity with an S(10) score of 0.01. BMX-IN-1 inhibits only wild-type BMX with an IC₅₀ of 138 nM. BMX-IN-1 requires covalent modification of Cys⁴⁹⁶ of BMX to achieve potent inhibition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1431525-23-3
Appearance Solid
Molecular Weight 524.59
Formel C₂₉H₂₄N₄O₄S
Color White to yellow
SMILES

O=C1N(C2=C(C=C1)C=NC3=CC=C(C4=CC=C(NS(=O)(C)=O)C=C4)C=C32)C5=CC=C(C)C(NC(C=C)=O)=C5
Synonyms

BMX kinase inhibitor
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (7)

All WB

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Journal Impact Factor

Nat Commun

Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]

2026 Feb 12;17(1):1214. PMID: 41680175
Cancer Lett

Fas signaling in adipocytes promotes low-grade inflammation and lung metastasis of colorectal cancer through interaction with Bmx. [Abstract]

2021 Dec 1:522:93-104. PMID: 34536556
Int J Biol Macromol

Bone marrow tyrosine kinase on chromosome X promotes epithelial-mesenchymal transition through signal transducer and activator of transcription 3 in colorectal cancer. [Abstract]

2026 Feb;344(Pt 1):150362. PMID: 41565140
JCI Insight

Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma. [Abstract]

2024 Jul 22;9(14):e169647. PMID: 39133652
Cell Mol Bioeng

Ibrutinib Inhibits BMX-Dependent Endothelial VCAM-1 Expression In Vitro and Pro-Atherosclerotic Endothelial Activation and Platelet Adhesion In Vivo. [Abstract]

2022 Apr 18;15(3):231-243. PMID: 35611166
Oncotarget

BMX/Etk promotes cell proliferation and tumorigenicity of cervical cancer cells through PI3K/AKT/mTOR and STAT3 pathways. [Abstract]

2017 Jul 25;8(30):49238-49252. PMID: 28514765

BMX-IN-1 purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Jul 25;8(30):49238-49252. [Abstract]

Western blot results show that the expression of BMX is decreased in both BMX-IN-1-treated HeLa and SiHa cells.
Harvard Medical School LINCS LIBRARY

Lösungsmittel & Löslichkeit

In Vitro:

DMF : 10 mg/mL (19.06 mM; Need ultrasonic)

DMSO : 8.33 mg/mL (15.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9063 mL

9.5313 mL

19.0625 mL

5 mM

0.3813 mL

1.9063 mL

3.8125 mL

10 mM

0.1906 mL

0.9531 mL

1.9063 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline

Solubility: 10 mg/mL (19.06 mM); Suspended solution; Need ultrasonic

Protokoll

Cell Assay^[1]

RV-1 cells in complete or serum-reduced DMEM are treated with DMSO, BMX-IN-1 (2.5 μM), MK2206 (200 nM), or the combination of BMX-IN-1 and MK2206 for 5 days before cells are harvested by trypsin and washed with cold PBS. The cells are then fixed in 70% cold ethanol (prechilled at −20°C) and incubated at 4°C overnight. On the day of flow cytometry, cells are collected by centrifugation, washed with PBS, and stained in 50 μg/mL propidium iodide + 0.5 mg/mL RNase in PBS + 0.5% Triton-X100 for 30 min at RT and moved to 4°C until the time of analysis. Flow cytometry is performed using a BD FACScan, and results are analyzed by ModFit software in the Flow Cytometry Core Facility in Dana-Faber Cancer Institute.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Feiyang Liu , et al. Discovery of a Selective Irreversible BMX Inhibitor for Prostate Cancer. ACS Chem. Biol., DOI: 10.1021/cb4000629

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / DMF	1 mM	1.9063 mL	9.5313 mL	19.0625 mL	47.6563 mL
	5 mM	0.3813 mL	1.9063 mL	3.8125 mL	9.5313 mL
	10 mM	0.1906 mL	0.9531 mL	1.9063 mL	4.7656 mL
	15 mM	0.1271 mL	0.6354 mL	1.2708 mL	3.1771 mL

Keywords

BMX-IN-1

7 Cited Publications

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BMX-IN-1

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Covalent Screening Library

Chemical Probe Library

Anti-Blood Cancer Compound Library

Targeted Diversity Library

Autoimmune Disease Compound Library

Highly Selective Inhibitors Library

Serine/Threonine Kinase Inhibitor Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

Kinase Inhibitor Library Mini

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) BMX-IN-1

Biologische Aktivität

Chemical Information

Publications (7)

Lösungsmittel & Löslichkeit

Protokoll

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

BMX-IN-1

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Covalent Screening Library

Chemical Probe Library

Anti-Blood Cancer Compound Library

Targeted Diversity Library

Autoimmune Disease Compound Library

Highly Selective Inhibitors Library

Serine/Threonine Kinase Inhibitor Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

Kinase Inhibitor Library Mini

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) BMX-IN-1

Biologische Aktivität

Chemical Information

Publications (7)

Lösungsmittel & Löslichkeit

Protokoll

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

BMX-IN-1 Related Classifications

HY-80002 Related Classifications