Dalfopristin
Based on 2 publication(s) in Google Scholar
Dalfopristin (RP54476) is a semisynthetic sulfone antibiotic. Dalfopristin alone has limited antibacterial activity, but synergistically with Quinupristin it has significant bactericidal activity against many pathogenic Gram-positive cocci.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.70%
- CAS. Nr.: 112362-50-2
- Formel: C34H50N4O9S
- Molecular Weight:690.85
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Publications Citing Use of MedChemExpress (MCE) Dalfopristin
MoreAlle Antibiotic Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
Antibacterial[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 112362-50-2
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Appearance Solid
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Molecular Weight 690.85
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Formel C34H50N4O9S
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Color White to yellow
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SMILES
O=S(CCN(CC)CC)([C@H]1[C@@](C(O[C@H]([C@@H](/C=C/C(NC/C=C\C(C)=C\2)=O)C)C(C)C)=O)([H])N(C(C3=COC(CC(C[C@@H]2O)=O)=N3)=O)CC1)=O
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Synonyms
RP54476
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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J Antibiot
In vitro synergistic effect of retapamulin with erythromycin and quinupristin against Enterococcus faecalis. [Abstract]2020 Sep;73(9):630-635. PMID: 32346089 -
Infect Dis Rep
Inadequate Cerebrospinal Fluid Concentrations of Available Salvage Agents Further Impedes the Optimal Treatment of Multidrug-Resistant Enterococcus faecium Meningitis and Bacteremia. [Abstract]2021 Sep 8;13(3):843-854. PMID: 34563001
Lösungsmittel & Löslichkeit
DMSO : ≥ 100 mg/mL (144.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.01 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.01 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (282 KB)
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SDS (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. A Le Liboux, et al. Simultaneous high-performance liquid chromatographic determination of quinupristin, dalfopristin and their main metabolites in human plasma. J Chromatogr B Biomed Sci Appl. 1998 Apr 24;708(1-2):161-8. [Content Brief]
[2]. Martinet MR, et al. Lack of effect of streptogramins on hepatic drug metabolism enzymes in the rat. Drug Metab Dispos. 1992 Jul-Aug;20(4):490-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4475 mL | 7.2375 mL | 14.4749 mL | 36.1873 mL |
| 5 mM | 0.2895 mL | 1.4475 mL | 2.8950 mL | 7.2375 mL | |
| 10 mM | 0.1447 mL | 0.7237 mL | 1.4475 mL | 3.6187 mL | |
| 15 mM | 0.0965 mL | 0.4825 mL | 0.9650 mL | 2.4125 mL | |
| 20 mM | 0.0724 mL | 0.3619 mL | 0.7237 mL | 1.8094 mL | |
| 25 mM | 0.0579 mL | 0.2895 mL | 0.5790 mL | 1.4475 mL | |
| 30 mM | 0.0482 mL | 0.2412 mL | 0.4825 mL | 1.2062 mL | |
| 40 mM | 0.0362 mL | 0.1809 mL | 0.3619 mL | 0.9047 mL | |
| 50 mM | 0.0289 mL | 0.1447 mL | 0.2895 mL | 0.7237 mL | |
| 60 mM | 0.0241 mL | 0.1206 mL | 0.2412 mL | 0.6031 mL | |
| 80 mM | 0.0181 mL | 0.0905 mL | 0.1809 mL | 0.4523 mL | |
| 100 mM | 0.0145 mL | 0.0724 mL | 0.1447 mL | 0.3619 mL |
Dalfopristin Related Classifications
HY-A0241 Related Classifications
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