Art. -Nr.: HY-N0784

Ginkgolide B

(Synonyms: BN-52021)

13 Cited Publications

Kundenbewertung

Based on 13 publication(s) in Google Scholar

Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments.

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Reinheit: 99.84%
CAS. Nr.: 15291-77-7
Formel: C₂₀H₂₄O₁₀
Molecular Weight:424.40

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Ginkgolide B Chemical Structure

CAS. Nr.: 15291-77-7

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (13)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Ginkgolide B (BN-52021; 30-150 μM; 24 h) inhibits the up-regulation of VCAM-1 and E-selectin protein expression induced by TNF-α (10 ng/mL)^[1].
Ginkgolide B (30-150 μM; 24, 48 h) increases CYP3A4 mRNA and MDR1 expression^[1].
Ginkgolide B (30-150 μM; pretreated for 24 h) reduces Staurosporine-induced (500 nM; 6 h) apoptosis compared with the positive controls, which exhibited marked apoptosis compared with negative controls. Ginkgolide B does not affect Doxorubicin (5 μM; 24 h) induced apoptosis^[1].
Ginkgolide B regulates PXR activity and does not affect PXR expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HUVECs
Concentration:

30, 60, 150 μM
Incubation Time:

24 h
Result:

Inhibited the up-regulation of VCAM-1 and E-selectin protein expression induced by TNF-α.

RT-PCR^[1]

Cell Line:

HUVECs
Concentration:

30, 60, 150 μM
Incubation Time:

24, 48 h
Result:

Increased CYP3A4 mRNA and MDR1 expression after 24 h, and this effect was dose-dependent after 48 h.

In Vivo

Ginkgolide B (BN-52021; 20 mg/kg; Intraperitoneally; immediately and 6 hours after ischemia, and thereafter once daily; 14 days) decreases the neurological deficit score^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male clean healthy Sprague-Dawley rats, weighing 250-280 g and aged 8 weeks^[2]
Dosage:

20 mg/kg
Administration:

Intraperitoneally; immediately and 6 hours after ischemia, and thereafter once daily; 14 days
Result:

Decreased the neurological deficit score, increased the proportion of nestin-, neuron-specific enolase- and glial fibrillary acid protein-positive cells.
Caused down-regulation of NSE protein at day 14.

Chemical Information

CAS. Nr. 15291-77-7
Appearance Solid
Molecular Weight 424.40
Formel C₂₀H₂₄O₁₀
Color White to off-white
SMILES

O[C@@H]1C(C2([C@H]3O)[C@](OC3=O)([H])O4)([C@@](O5)([H])C[C@H]2C(C)(C)C)C4(C5=O)[C@@](O)([C@@H]6C)[C@@]1([H])OC6=O
Synonyms

BN-52021
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (13)

All WBCell Proliferation/Viability AssayRT-PCRHistological Imaging/StainingIHCIF

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Journal Impact Factor

Adv Healthc Mater

Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti-Apoptotic, and Neurotrophic Treatments. [Abstract]

2026 Jun;15(21):e05595. PMID: 41937329
J Agric Food Res

2025 Nov 24.
Neurobiol Dis

Nuclear localization of platelet activating factor receptor accounts for microglial phagocytosis in ischemic stroke. [Abstract]

2025 Sep:213:107020. PMID: 40623479
Int Immunopharmacol

Ginkgolide B attenuates post-stroke cognitive impairment via exosomal miR-299a-3p regulation of the TRIL/PI3K/AKT pathway. [Abstract]

2026 May 1:176:116479. PMID: 41819672
Biofactors

Ginkgolide B and bilobalide promote the growth and increase β-catenin expression in hair follicle dermal papilla cells of American minks. [Abstract]

2019 Nov;45(6):950-958. PMID: 31520488
Neuropharmacology

Ginkgolide B can alleviate spinal cord glymphatic system dysfunction and provide neuroprotection in painful diabetic neuropathy rats by inhibiting matrix metalloproteinase-9. [Abstract]

2024 Jun 1:250:109907. PMID: 38492884
Brain Res Bull

Ginkgolide B alleviates cerebral ischemia-reperfusion injury by antagonizing TRIM45 to reduce microglia-mediated neuronal damage. [Abstract]

2026 Jun 1:239:111854. PMID: 41921864
Hum Genomics

Identifying PTAFR as a hub gene in atherosclerosis: implications for NETosis and disease progression. [Abstract]

2024 Dec 21;18(1):139. PMID: 39709510
Bone

Inhibiting autophagy further promotes Ginkgolide B's anti-osteoclastogenesis ability. [Abstract]

2024 Nov 29:192:117348. PMID: 39617111
Toxicol Appl Pharmacol

Ginkgolide B binds to GPX4 and FSP1 to alleviate cerebral ischemia/reperfusion injury in rats. [Abstract]

2025 Jan 22:495:117237. PMID: 39855311
Biomed Pharmacother

Antagonizing epigenetically controlled PAF/PAF-R pathway improves liver function during experimental cirrhosis. [Abstract]

2025 Nov 20:193:118804. PMID: 41270474

Ginkgolide B purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Nov 20:193:118804. [Abstract]

Representative images of western blot of whole liver lysates from control and cirrhotic mice intraperitoneally injected with Ginkgolide B (BN-52021) (15 mg/kg; i.p.; three times a week for 2 weeks) or DMSO as vehicle, both diluted in sterile PBS; and band densitometry of PAF-R signal with relative quantification respect to loading control β-actin.

Ginkgolide B purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Nov 20:193:118804. [Abstract]

mRNA relative expression of Tbxa2r, Tbxas1, Edn1, Vwf in mice total liver homogenates respect to housekeeping gene β-actin. Ginkgolide B (BN-52021) (15 mg/kg; i.p.; three times a week for 2 weeks) improved endothelial function in cirrhotic mice by antagonizing PAF, as evidenced by significantly reduced expression levels of Tbxa2r, Tbxas1, Edn1, and Vwf.

Ginkgolide B purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Nov 20:193:118804. [Abstract]

mRNA relative expression, normalized to housekeeping gene β-actin of Rorc. Respectively, representative images of RorγT staining in liver and their respective quantifications are shown in the same panels. Signal from the immunohistochemistry staining experiments was blindly measured as number of positive cells/mm² (pointed by arrowheads) in user-specified regions of interest (ROIs) as brown stained nuclear signals colocalizing with blue haematoxylin-stained nuclei. Scale bar = 100 µm. The results showed that the expression of RorgTand the number of RorgT⁺ cells were significantly reduced in the livers of Ginkgolide B (BN-52021) (15 mg/kg; i.p.; three times a week for 2 weeks)-treated cirrhotic mice compared with untreated cirrhotic controls.
Biomed Pharmacother

Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats. [Abstract]

2024 Jun 21:177:117006. PMID: 38908197

Ginkgolide B purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Jun 21:177:117006. [Abstract]

The effects of varying Ginkgolide B (GB) concentrations (5, 10, 20, 30, 40, 50, 100, 200, and 400 μM) for 24 h on microglial cell viability (n=6) were assessed.

Ginkgolide B purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Jun 21:177:117006. [Abstract]

HE staining images of the heart, liver, spleen, lungs, kidneys, and brain of rats intraperitoneally injected with 4 mg/kg Ginkgolide B (GB) (twice daily) or 10 mg/kg gabapentin were used to assess drug toxicity. Scale bar = 50 μm (n=3). H&E staining of animal models s confirmed that the therapeutic concentration of GB exerted no drug toxicity.

Ginkgolide B purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Jun 21:177:117006. [Abstract]

Immunohistochemical images and quantification of Iba-1 in the dorsal horn of the spinal cord of rats intraperitoneally injected with 4 mg/kg Ginkgolide B (GB) (twice daily) or 10 mg/kg gabapentin. Scale bar = 100 μm (n=3).

Ginkgolide B purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Jun 21:177:117006. [Abstract]

Ginkgolide B (GB, 1–4 mg/kg, i.p.) suppressed the levels of IL-1β, Caspase-1, IL-18, Iba-1, and NLRP3 in a dose-dependent manner in the rat spinal cord.

Ginkgolide B purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Jun 21:177:117006. [Abstract]

Immunofluorescence images of co-localisation of ASC (green) and NLRP3 (red) in microglial cells after pretreatment with LPS (500 ng/mL; 4 h), ATP (5 mM; 10 min), Ginkgolide B (GB) (40 μM; 2 h) or Si-Parkin. Scale bar = 25 μm (n=3).
Research Square Print

2022 Jun.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (235.63 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3563 mL

11.7813 mL

23.5627 mL

5 mM

0.4713 mL

2.3563 mL

4.7125 mL

10 mM

0.2356 mL

1.1781 mL

2.3563 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.89 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.89 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.89 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 0.5% CMC-Na/saline water

Solubility: 5 mg/mL (11.78 mM); Suspended solution; Need ultrasonic and warming and heat to 44°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Tao Zhou, et al. Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation. Acta Pharmacol Sin. 2016 Feb;37(2):177-86. [Content Brief]

[2]. Pei-Dong Zheng, et al. Ginkgolide B promotes the proliferation and differentiation of neural stem cells following cerebral ischemia/reperfusion injury, both in vivo and in vitro. Neural Regen Res. 2018 Jul;13(7):1204-1211. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3563 mL	11.7813 mL	23.5627 mL	58.9067 mL
	5 mM	0.4713 mL	2.3563 mL	4.7125 mL	11.7813 mL
	10 mM	0.2356 mL	1.1781 mL	2.3563 mL	5.8907 mL
	15 mM	0.1571 mL	0.7854 mL	1.5708 mL	3.9271 mL
	20 mM	0.1178 mL	0.5891 mL	1.1781 mL	2.9453 mL
	25 mM	0.0943 mL	0.4713 mL	0.9425 mL	2.3563 mL
	30 mM	0.0785 mL	0.3927 mL	0.7854 mL	1.9636 mL
	40 mM	0.0589 mL	0.2945 mL	0.5891 mL	1.4727 mL
	50 mM	0.0471 mL	0.2356 mL	0.4713 mL	1.1781 mL
	60 mM	0.0393 mL	0.1964 mL	0.3927 mL	0.9818 mL
	80 mM	0.0295 mL	0.1473 mL	0.2945 mL	0.7363 mL
	100 mM	0.0236 mL	0.1178 mL	0.2356 mL	0.5891 mL

Ginkgolide B

13 Cited Publications

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Ginkgolide B

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Publications Citing Use of MedChemExpress (MCE) Ginkgolide B

Biologische Aktivität

Chemical Information

Publications (13)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Ginkgolide B Related Classifications

HY-N0784 Related Classifications