Antitumor agent-145
Antitumor agent-145 (Compound Ir5) is a tumor inhibitor with remarkable fluorescence and mitochondrial targeting, which exerts anti-cancer effects by inducing necroptosis and activating the necroptosis-related immune response.
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- CAS. Nr.: 2983120-65-4
- Formel: C44H34IrN5OS
- Molecular Weight:873.06
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Antitumor agent-145 (Compound Ir5) (48 h) could effectively reduce the cell viability of BEL-7402/DDP cells with IC50 value of 0.49 μM and a resistance coefficient (RF) of 1.04. No obvious cytotoxicity Antitumor agent-145[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Antitumor agent-145 (1.5 or 3.0 mg/kg, intravenous injection, every other day for 21 days) BEL-7402/DDP tumor xenograft models can significantly inhibit the growth and metastasis of CDDP resistant tumors without causing obvious tissue damage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice
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Dosage:NaCl, CDDP (3 mg/kg), Ir5 (1.5 mg/kg), and Ir5 (3 mg/kg)
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Administration:every other day for 21 days
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Result:The tumor volume in BALB/c mice was significantly reduced, and there was no significant difference in the weight of major organs.
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Animal Model:BEL-7402/DDP tumor xenograft models
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Dosage:1.5 mg/kg or 3 mg/kg
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Administration:every 2 days for 21 days
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Result:The results revealed that Ir5 significantly decreases the tumor volume, with an inhibition rate of tumor growth (IRT) of 40.0% at a dose of 1.5 mg/kg and 58.1% at a dose of 3 mg/kg, compared to only 10.1% in the CDDP group. No obvious tissue injury.
Chemical Information
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CAS. Nr. 2983120-65-4
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Molecular Weight 873.06
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Formel C44H34IrN5OS
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SMILES
OC1=C(C2=CC=CC=C2C=C1)/C=[N]3N=C(N(C)C)[S-][Ir+3]\345([N]6=C(C7=C(C=C6)C=CC=C7)C8=CC=CC=[C-]85)[N]9=C(C%10=C(C=C9)C=CC=C%10)C%11=CC=CC=[C-]%114
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (284 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Antitumor agent-145 Related Classifications
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