Art. -Nr.: HY-145351

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BAY 1003803

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BAY 1003803 is a glucocorticoid receptor agonist for the topical research of psoriasis or severe atopic dermatitis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.85%
CAS. Nr.: 1152781-51-5
Formel: C₂₁H₁₈ClF₅N₂O₄
Molecular Weight:492.82

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

BAY 1003803 Chemical Structure

CAS. Nr.: 1152781-51-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

BAY 1003803 is a glucocorticoid receptor agonist for the topical research of psoriasis or severe atopic dermatitis.

Cellular Effect

Cell Line	Type	Value	Description	References
PBMC	IC₅₀	0.42 nM Compound: BAY 1003803	Inhibition of PHA-induced IL4 release in human PBMC cells Inhibition of PHA-induced IL4 release in human PBMC cells	[PMID: 32631518]
PBMC	IC₅₀	0.7 nM Compound: BAY 1003803	Inhibition of PHA-induced IFNgamma release in human PBMC cells Inhibition of PHA-induced IFNgamma release in human PBMC cells	[PMID: 32631518]
PBMC	IC₅₀	0.75 nM Compound: BAY 1003803	Inhibition of LPS-induced IL12p40 release in human PBMC cells Inhibition of LPS-induced IL12p40 release in human PBMC cells	[PMID: 32631518]
PBMC	IC₅₀	0.88 nM Compound: BAY 1003803	Inhibition of PHA-induced IL2 release in human PBMC cells Inhibition of PHA-induced IL2 release in human PBMC cells	[PMID: 32631518]
PBMC	IC₅₀	0.92 nM Compound: BAY 1003803	Inhibition of LPS-induced TNFalpha release in human PBMC cells Inhibition of LPS-induced TNFalpha release in human PBMC cells	[PMID: 32631518]

Chemical Information

CAS. Nr. 1152781-51-5
Appearance Solid
Molecular Weight 492.82
Formel C₂₁H₁₈ClF₅N₂O₄
Color White to off-white
SMILES

FC1=CC(N[C@@H](C2=C(C(F)=C(C=C2)OC)Cl)[C@](C(F)(F)F)(O)COC)=C3C(NC(C=C3)=O)=C1
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (202.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0291 mL

10.1457 mL

20.2914 mL

5 mM

0.4058 mL

2.0291 mL

4.0583 mL

10 mM

0.2029 mL

1.0146 mL

2.0291 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.07 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.07 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Berger M, et al. Discovery of the potent non-steroidal glucocorticoid receptor modulator BAY 1003803 as clinical candidate. Bioorg Med Chem Lett. 2020 Aug 15;30(16):127298. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0291 mL	10.1457 mL	20.2914 mL	50.7285 mL
	5 mM	0.4058 mL	2.0291 mL	4.0583 mL	10.1457 mL
	10 mM	0.2029 mL	1.0146 mL	2.0291 mL	5.0728 mL
	15 mM	0.1353 mL	0.6764 mL	1.3528 mL	3.3819 mL
	20 mM	0.1015 mL	0.5073 mL	1.0146 mL	2.5364 mL
	25 mM	0.0812 mL	0.4058 mL	0.8117 mL	2.0291 mL
	30 mM	0.0676 mL	0.3382 mL	0.6764 mL	1.6909 mL
	40 mM	0.0507 mL	0.2536 mL	0.5073 mL	1.2682 mL
	50 mM	0.0406 mL	0.2029 mL	0.4058 mL	1.0146 mL
	60 mM	0.0338 mL	0.1691 mL	0.3382 mL	0.8455 mL
	80 mM	0.0254 mL	0.1268 mL	0.2536 mL	0.6341 mL
	100 mM	0.0203 mL	0.1015 mL	0.2029 mL	0.5073 mL

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BAY 1003803

MCE Bioactive Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

BAY 1003803 Related Classifications

HY-145351 Related Classifications