BuChE-IN-22
BuChE-IN-22 is a pseudo-irreversible butyrylcholinesterase (BuChE) inhibitor, with IC50 values of 4 nM and 157 nM against hBuChE and hAChE, respectively. It also acts as a prodrug of 7-hydroxysertraline. BuChE-IN-22 releases 7-hydroxysertraline during BuChE inhibition. BuChE-IN-22 completely reverses Aβ25-35-induced short-term and long-term memory impairments in a mouse model of Alzheimer's disease. BuChE-IN-22 can be used in research related to Alzheimer's disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C23H26Cl2N2O2
- Molecular Weight:433.37
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
hBCHE 4 nM (IC50) |
hAChE 157 nM (IC50) |
In Vitro
BuChE-IN-22 (Compound 8e) (255 μM; 48 h) remains stable in the absence of hBuChE, but is completely metabolized by hBuChE within 48 h, releasing 85% of the serotonin reuptake inhibitor HO-Sert[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Swiss mice (male, 6 weeks old, 30-35 g, intracerebroventricular injection of 9 nmol oligomeric Aβ25-35 peptide)[1]
-
Dosage:0.3 mg/kg; 1 mg/kg (long-term non-spatial memory); 3 mg/kg (spatial working memory)
-
Administration:i.p.; daily; 7 days (starting 20 minutes post-Aβ25-35 injection)
-
Result:Completely prevented Aβ25-35-induced deficits in spontaneous alternation (spatial working memory) at 3 mg/kg.
Completely prevented Aβ25-35-induced deficits in passive avoidance retention latency (long-term non-spatial memory) at 1 mg/kg.
Chemical Information
-
Molecular Weight 433.37
-
Formel C23H26Cl2N2O2
-
SMILES
CN[C@H]1CC[C@@H](C2=CC=C(Cl)C(Cl)=C2)C3=C1C=C(OC(N4CCCCC4)=O)C=C3
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
BuChE-IN-22 Related Classifications
HY-181865 Related Classifications
Powered by Bioz