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Art. -Nr.: HY-156789

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CD38-IN-4

CD38-IN-4 is a CD38 inhibitor. CD38-IN-4 inhibits CD38 hydrolase enzymatic activity through mixed inhibition kinetics, binding partially inside and partially outside the NAD⁺ catalytic pocket. CD38-IN-4 acts as a DNA-binding agent. CD38-IN-4 can be used for research on neuroblastoma.

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CAS. Nr.: 524055-93-4
Formel: C₁₈H₂₃N₅
Molecular Weight:309.42

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

CD38-IN-4 Chemical Structure

CAS. Nr.: 524055-93-4

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One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
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Bioz

Biologische Aktivität

Beschreibung

In Vitro

Anti-cancerOthers

Anti-cancer

CD38-IN-4 (compound 2) (72 h) exhibits cytotoxicity against SF767 glioblastoma cells with an LC₅₀ of 2.6 μM^[2].

Others

CD38-IN-4 (compound 13) (50 μM; 15 minutes) inhibits human recombinant CD38 hydrolase activity with an IC₅₀ of 22.4 μM^[1].
CD38-IN-4 (1.0 μM; 24 hours) does not affect the proliferation of SHSY5Y-GFP neuroblastoma cells at 1.0 μM over 24 hours^[1].
CD38-IN-4 (10 μM) binds to calf thymus DNA in the HT-FID assay^[2].
CD38-IN-4 (15-20 μM) binds preferentially to A/T-rich DNA, as indicated by thermal melting studies^[2].
CD38-IN-4 (7.7 μM) is a reasonably strong DNA-binding agent relative to control agents^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 524055-93-4
Molecular Weight 309.42
Formel C₁₈H₂₃N₅
SMILES

N=1C(=NC(=C2C=CC(=CC12)CC)C)NC3=NC(=CC(N3)(C)C)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Mills CM, et al. Stimulation of natural killer cells with small molecule inhibitors of CD38 for the treatment of neuroblastoma. Chemical science. 2023 Feb 22;14(8):2168-2182.

[2]. Glass LS, et al. Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound library. Bioorganic & medicinal chemistry letters. 2010 Mar 01;20(5):1685-8.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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