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Art. -Nr.: HY-162637

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CTL26

CTL26 is a potent and orally active α-glucosidase inhibitor with an IC₅₀ value of 2.81 µM. CTL26 shows anti-diabetic efficacy.

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CAS. Nr.: 3047448-30-3
Formel: C₂₅H₁₈N₆O₃S
Molecular Weight:482.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

CTL26 Chemical Structure

CAS. Nr.: 3047448-30-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

CTL26 is a potent and orally active α-glucosidase inhibitor with an IC₅₀ value of 2.81 µM. CTL26 shows anti-diabetic efficacy^[1].

IC₅₀ & Target

IC₅₀: 2.81 µM (α-glucosidase)^[1]

In Vivo

CTL26 (25, 50 mg/kg; p.o.; daily for 4 weeks) shows anti-diabetic efficacy in streptozocin (HY-13753)-induced diabetes mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

10-15g, SPF C57/6 J male mice (STZ-induced diabetes)^[1]
Dosage:

25, 50 mg/kg
Administration:

P.o.; daily for 4 weeks
Result:

Exhibited continuously decreasing fasting blood glucose (FBG) levels, decreased the serum total cholesterol (TC) and triglycerides (TG) levels.

Chemical Information

CAS. Nr. 3047448-30-3
Molecular Weight 482.51
Formel C₂₅H₁₈N₆O₃S
SMILES

O=C(NNC(NC1=CC([N+]([O-])=O)=CC=C1)=S)C2=CC3=C(C(C4=CC=CC=C4)=N2)NC5=CC=CC=C53
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Liang B, et al. Novel thiosemicarbazide-based β-carboline derivatives as α-glucosidase inhibitors: Synthesis and biological evaluation. Eur J Med Chem. 2024 Jun 12;275:116595. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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