FLT3-IN-16
Based on 1 Customer Validation
FLT3-IN-16 is a potent FLT3 inhibitor with an IC50 of 1.1 μM. FLT3-IN-16 can be used for researching acute myeloid leukemia.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98.98%
- CAS. Nr.: 298207-49-5
- Formel: C15H15N3O2S
- Molecular Weight:301.36
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
IC50: 1.1 μM (FLT3)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | CC50 |
>250 μM
Compound: 8
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Cytotoxicity against human HEK293T cells after 24 hrs by MTT assay
Cytotoxicity against human HEK293T cells after 24 hrs by MTT assay
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[PMID: 24785979] |
| MDCK | CC50 |
45.2 μM
Compound: 8
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Cytotoxicity against MDCK cells after 48 hrs by MTT assay
Cytotoxicity against MDCK cells after 48 hrs by MTT assay
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[PMID: 24785979] |
| MV4-11 | IC50 |
2 μM
Compound: 9
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Antiproliferative activity against human MV4-11 cells
Antiproliferative activity against human MV4-11 cells
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[PMID: 16580199] |
In Vitro
FLT3-IN-16 (compound 9, 0-10 μM) exhibits anti-proliferative activities against MV4-11 cells with an IC50 value of 2.0 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 298207-49-5
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Appearance Solid
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Molecular Weight 301.36
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Formel C15H15N3O2S
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Color Off-white to light yellow
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SMILES
O=C(C1=C(NC(C2=CC=CN=C2)=O)SC3=C1CCCC3)N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 25 mg/mL (82.96 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3183 mL | 16.5915 mL | 33.1829 mL | 82.9573 mL |
| 5 mM | 0.6637 mL | 3.3183 mL | 6.6366 mL | 16.5915 mL | |
| 10 mM | 0.3318 mL | 1.6591 mL | 3.3183 mL | 8.2957 mL | |
| 15 mM | 0.2212 mL | 1.1061 mL | 2.2122 mL | 5.5305 mL | |
| 20 mM | 0.1659 mL | 0.8296 mL | 1.6591 mL | 4.1479 mL | |
| 25 mM | 0.1327 mL | 0.6637 mL | 1.3273 mL | 3.3183 mL | |
| 30 mM | 0.1106 mL | 0.5530 mL | 1.1061 mL | 2.7652 mL | |
| 40 mM | 0.0830 mL | 0.4148 mL | 0.8296 mL | 2.0739 mL | |
| 50 mM | 0.0664 mL | 0.3318 mL | 0.6637 mL | 1.6591 mL | |
| 60 mM | 0.0553 mL | 0.2765 mL | 0.5530 mL | 1.3826 mL | |
| 80 mM | 0.0415 mL | 0.2074 mL | 0.4148 mL | 1.0370 mL |
FLT3-IN-16 Related Classifications
HY-148036 Related Classifications
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