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Art. -Nr.: HY-155770

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FLT3-IN-20

FLT3-IN-20 (compound 34f) is a potent FLT3 inhibitor with IC₅₀ values of 1 and 4 nM for FLT3-D835Y and FLT3-ITD, respectively. FLT3-IN-20 has anti-proliferation efficacy in FLT3-ITD-positive AML cell lines MV4-11 and MOLM-13 (7 and 9 nM, respectively) and the MOLM-13 variant (4 nM) with the FLT3-ITD-D835Y mutation. FLT3-IN-20 can be used in research of cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₈H₃₃N₇O₂S
Molecular Weight:531.67

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

FLT3-IN-20 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	GI₅₀	1.768 μM Compound: 34f	Antiproliferative activity against FLT3-independent human CEM cells assessed as cell growth inhibition by resorufin dye based fluorescence analysis Antiproliferative activity against FLT3-independent human CEM cells assessed as cell growth inhibition by resorufin dye based fluorescence analysis	[PMID: 37535845]
K562	GI₅₀	1.525 μM Compound: 34f	Antiproliferative activity against FLT3-independent human K562 cells assessed as cell growth inhibition by resorufin dye based fluorescence analysis Antiproliferative activity against FLT3-independent human K562 cells assessed as cell growth inhibition by resorufin dye based fluorescence analysis	[PMID: 37535845]
Kasumi 1	GI₅₀	0.188 μM Compound: 34f	Antiproliferative activity against human Kasumi 1 cells harboring KIT N822K mutant assessed as cell growth inhibition by resorufin dye based fluorescence analysis Antiproliferative activity against human Kasumi 1 cells harboring KIT N822K mutant assessed as cell growth inhibition by resorufin dye based fluorescence analysis	[PMID: 37535845]
ML-2	GI₅₀	3.03 μM Compound: 34f	Antiproliferative activity against FLT3-independent human ML-2 cells assessed as cell growth inhibition by resorufin dye based fluorescence analysis Antiproliferative activity against FLT3-independent human ML-2 cells assessed as cell growth inhibition by resorufin dye based fluorescence analysis	[PMID: 37535845]
MOLM-13	GI₅₀	0.004 μM Compound: 34f	Antiproliferative activity against drug-resistant human MOLM-13 cells expressing FLT3-ITD-D835Y mutant assessed as cell growth inhibition incubated for 72 hrs by resorufin dye based fluorescence analysis Antiproliferative activity against drug-resistant human MOLM-13 cells expressing FLT3-ITD-D835Y mutant assessed as cell growth inhibition incubated for 72 hrs by resorufin dye based fluorescence analysis	[PMID: 37535845]
MOLM-13	GI₅₀	0.009 μM Compound: 34f	Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as cell growth inhibition by resorufin dye based fluorescence analysis Antiproliferative activity against human MOLM-13 cells harboring FLT3-ITD mutant assessed as cell growth inhibition by resorufin dye based fluorescence analysis	[PMID: 37535845]
MOLM-13	GI₅₀	0.01 μM Compound: 34f	Antiproliferative activity against FLT3-dependent human MOLM-13 cells assessed as cell growth inhibition incubated for 72 hrs by resorufin dye based fluorescence analysis Antiproliferative activity against FLT3-dependent human MOLM-13 cells assessed as cell growth inhibition incubated for 72 hrs by resorufin dye based fluorescence analysis	[PMID: 37535845]
MV4-11	GI₅₀	0.007 μM Compound: 34f	Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as cell growth inhibition by resorufin dye based fluorescence analysis Antiproliferative activity against human MV4-11 cells harboring FLT3-ITD mutant assessed as cell growth inhibition by resorufin dye based fluorescence analysis	[PMID: 37535845]
NOMO-1	GI₅₀	4.275 μM Compound: 34f	Antiproliferative activity against FLT3-independent human NOMO-1 cells assessed as cell growth inhibition by resorufin dye based fluorescence analysis Antiproliferative activity against FLT3-independent human NOMO-1 cells assessed as cell growth inhibition by resorufin dye based fluorescence analysis	[PMID: 37535845]
SEM	GI₅₀	0.14 μM Compound: 34f	Antiproliferative activity against human SEM cells overexpressing wild type FLT3 assessed as cell growth inhibition by resorufin dye based fluorescence analysis Antiproliferative activity against human SEM cells overexpressing wild type FLT3 assessed as cell growth inhibition by resorufin dye based fluorescence analysis	[PMID: 37535845]

Chemical Information

Molecular Weight 531.67
Formel C₂₈H₃₃N₇O₂S
SMILES

O=S(C1=CC=C(NC2=CC(N[C@@H]3CC[C@@H](N)CC3)=NN4C2=NC=C4C5=CC=CC=C5)C=C1)(N6CCCC6)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Břehová P, et, al. Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping. J Med Chem. 2023 Aug 24;66(16):11133-11157. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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