RAB31 - RAB31, member RAS oncogene family Gene

Also Known as Rab22B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11031

About RAB31

Cytogenetic location: 18p11.22 Genomic coordinates (GRCh38): 18:9,708,301-9,862,551 (from NCBI)

This gene has 12 transcripts (splice variants), 201 orthologues and 68 paralogues. Broad expression in brain (RPKM 65.3), adrenal (RPKM 60.7) and 22 other tissues.

Summary

Small GTP-binding proteins of the RAB family, such as RAB31, play essential roles in vesicle and granule targeting (Bao et al., 2002 [PubMed 11784320]).[supplied by OMIM, Jul 2009]

RAB31 Products (1)

mRNA Protein Name
NM_006868.4 NP_006859.2 ras-related protein Rab-31

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables GDP binding IDA
IDA: Inferred from direct assay
17189207 GOA
enables GTP binding IDA
IDA: Inferred from direct assay
17189207 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23055524 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in Golgi to plasma membrane protein transport IMP
IMP: Inferred from mutant phenotype
17678623 GOA
involved in cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
17189207 GOA
involved in phagosome maturation IMP
IMP: Inferred from mutant phenotype
21255211 GOA
involved in receptor internalization IMP
IMP: Inferred from mutant phenotype
19725050 GOA
involved in regulated exocytosis IMP
IMP: Inferred from mutant phenotype
17189207 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in early endosome IDA
IDA: Inferred from direct assay
17189207 GOA
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
21255211 GOA
located in trans-Golgi network membrane IDA
IDA: Inferred from direct assay
17678623 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB31 Protein Structure

Ras

Ras: Ras family (8 - 167)

  • 0
  • 100
  • 195 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-31

  • ras-related protein Rab-22B

RAB31 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
RAB31 Q13636 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra
RAB31 Q13636 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra
RAB31 Q13636 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra
RAB31 Q13636 ALS2CL Homo sapiens Q60I27
Y2H Array
32296183
Intra
RAB31 Q13636 ALS2CL Homo sapiens Q60I27
Y2H Prey Pooling
32296183
Intra
RAB31 Q13636 ALS2CL Homo sapiens Q60I27
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RAB31 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P76561 RAB31 Protein, Human (His) Q13636/NP_006859 (M1-C195) ≥ 90%, as determined by reducing SDS-PAGE.

RAB31 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P89799 Rab 31 Antibody (YA9143) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Diseases

Diseases Alias
Choroid Cancer

  • Choroid Neoplasm

  • Choroidal Tumor

  • Malignant Tumor Of Choroid

  • Malignant Tumor Of The Choroid

  • Neoplasm Of Choroid

  • Choroid Neoplasms

  • Primary Malignant Neoplasm Of Choroid
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS19030 Rab31 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11544 RAB31 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25519 Rab31 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RAB31 MGD MGI:1914603
Canis familiaris RAB31 VGNC VGNC:45274
Rattus norvegicus RAB31 RGD RGD:628598
Bos taurus RAB31 VGNC VGNC:33640
Macaca mulatta RAB31 VGNC VGNC:104239
Others RAB31 NCBI