PPTC7 - protein phosphatase targeting COQ7 Gene

Also Known as TAPP2C; TA-PP2C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 160760

About PPTC7

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:110,533,245-110,583,318 (from NCBI)

This gene has 2 transcripts (splice variants) and 278 orthologues. Ubiquitous expression in bone marrow (RPKM 18.8), heart (RPKM 15.4) and 25 other tissues.

Summary

Enables protein serine/threonine Phosphatase activity. Involved in peptidyl-serine dephosphorylation and regulation of ubiquinone biosynthetic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

PPTC7 Products (1)

mRNA Protein Name
NM_139283.2 NP_644812.1 protein phosphatase PTC7 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
27499296 GOA
enables protein serine/threonine phosphatase activity IMP
IMP: Inferred from mutant phenotype
30267671 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in peptidyl-serine dephosphorylation IMP
IMP: Inferred from mutant phenotype
30267671 GOA
involved in regulation of ubiquinone biosynthetic process IMP
IMP: Inferred from mutant phenotype
30267671 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in mitochondrial matrix IMP
IMP: Inferred from mutant phenotype
30267671 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPTC7 Protein Structure

SpoIIE

SpoIIE: Stage II sporulation protein E (SpoIIE) (74 - 296)

  • 0
  • 100
  • 200
  • 304 a.a.
Protein Preferred Names Protein Names

protein phosphatase PTC7 homolog

  • PTC7 protein phosphatase homolog

PPTC7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PPTC7 Q8NI37 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
PPTC7 Q8NI37 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
PPTC7 Q8NI37 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
PPTC7 Q8NI37 NEFL Homo sapiens P07196
Validated Y2H
32814053
Intra
PPTC7 Q8NI37 NEFL Homo sapiens P07196
Y2H Array
32814053
Intra
PPTC7 Q8NI37 NEFL Homo sapiens P07196
Y2H Pooling
32814053
Intra
PPTC7 Q8NI37 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
PPTC7 Q8NI37 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
PPTC7 Q8NI37 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
PPTC7 Q8NI37 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
PPTC7 Q8NI37 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
PPTC7 Q8NI37 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
PPTC7 Q8NI37 PBXIP1 Homo sapiens Q96AQ6
Validated Y2H
32296183
Intra
PPTC7 Q8NI37 BNIP3 Homo sapiens Q12983
Anti Tag CoIP
27499296
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11040 PPTC7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PPTC7 VGNC VGNC:44931
Felis catus PPTC7 VGNC VGNC:64336
Mus musculus PPTC7 MGD MGI:2444593
Bos taurus PPTC7 VGNC VGNC:33278
Rattus norvegicus PPTC7 RGD RGD:1310383
Others PPTC7 NCBI