ELL2 - elongation factor for RNA polymerase II 2 Gene

Also Known as MRCCAT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22936

About ELL2

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:95,885,098-95,961,851 (from NCBI)

This gene has 8 transcripts (splice variants), 211 orthologues and 5 paralogues. Ubiquitous expression in esophagus (RPKM 18.5), salivary gland (RPKM 14.3) and 25 other tissues.

Summary

Involved in snRNA transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]

ELL2 Products (1)

mRNA Protein Name
NM_012081.6 NP_036213.2 RNA polymerase II elongation factor ELL2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
21729782 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in snRNA transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22195968 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of transcription elongation factor complex IDA
IDA: Inferred from direct assay
22195968 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELL2 Protein Structure

ELL

ELL: RNA polymerase II elongation factor ELL (11 - 291)

Occludin_ELL

Occludin_ELL: Occludin homology domain (532 - 633)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 600
  • 640 a.a.
Protein Preferred Names Protein Names

RNA polymerase II elongation factor ELL2

  • ELL-related RNA polymerase II, elongation factor

ELL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ELL2 O00472 PRKAB2 Homo sapiens O43741
Validated Y2H
32296183
Intra
ELL2 O00472 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra
ELL2 O00472 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra
ELL2 O00472 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra
ELL2 O00472 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
ELL2 O00472 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
ELL2 O00472 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
ELL2 O00472 EXOC8 Homo sapiens Q8IYI6
Validated Y2H
32296183
Intra
ELL2 O00472 AFF4 Homo sapiens Q8TAX5
Validated Y2H
32296183
Intra
ELL2 O00472 EAF1 Homo sapiens Q96JC9
Validated Y2H
32296183
Intra
ELL2 O00472 EAF1 Homo sapiens Q96JC9
Anti Tag CoIP
21729782
Intra
ELL2 O00472 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra
ELL2 O00472 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra
ELL2 O00472 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra
ELL2 O00472 SNCA Homo sapiens P37840
Validated Y2H
32814053
Intra
ELL2 O00472 SNCA Homo sapiens P37840
Y2H Array
32814053
Intra
ELL2 O00472 SNCA Homo sapiens P37840
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS04309 ELL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18930 Ell2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25420 Ell2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ELL2 VGNC VGNC:97416
Canis familiaris ELL2 VGNC VGNC:40307
Bos taurus ELL2 VGNC VGNC:28436
Macaca mulatta ELL2 VGNC VGNC:84368
Mus musculus ELL2 MGD MGI:2183438
Rattus norvegicus ELL2 RGD RGD:1309296
Others ELL2 NCBI