PSME4 - proteasome activator subunit 4 Gene

Also Known as PA200

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23198

About PSME4

Cytogenetic location: 2p16.2 Genomic coordinates (GRCh38): 2:53,864,069-53,970,993 (from NCBI)

This gene has 9 transcripts (splice variants) and 290 orthologues. Broad expression in testis (RPKM 32.8), endometrium (RPKM 14.4) and 24 other tissues.

Summary

Predicted to enable lysine-acetylated histone binding activity; peptidase activator activity; and Proteasome binding activity. Predicted to be involved in DNA repair; proteasomal ubiquitin-independent protein catabolic process; and spermatogenesis, exchange of chromosomal proteins. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PSME4 Products (1)

mRNA Protein Name
NM_014614.3 NP_055429.2 proteasome activator complex subunit 4

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
18845680 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSME4 Protein Structure

DUF3437

DUF3437: Domain of unknown function (DUF3437) (1756 - 1843)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1843 a.a.
Protein Preferred Names Protein Names

proteasome activator complex subunit 4

  • proteasome (prosome, macropain) activator subunit 4

PSME4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PSME4 Q14997 NUTM1 Homo sapiens Q86Y26
Validated Y2H
25416956
Intra
PSME4 Q14997 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
Intra
PSME4 Q14997 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Angelman Syndrome

  • AS

  • Happy Puppet Syndrome

  • Happy Puppet Syndrome, Formerly

  • Puppetlike Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11334 PSME4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PSME4 MGD MGI:2143994
Felis catus PSME4 VGNC VGNC:81160
Macaca mulatta PSME4 VGNC VGNC:76295
Bos taurus PSME4 VGNC VGNC:33476
Rattus norvegicus PSME4 RGD RGD:1591971
Canis familiaris PSME4 VGNC VGNC:45119
Others PSME4 NCBI