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SUMF2 - sulfatase modifying factor 2 Gene

Also Known as pFGE

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25870

About SUMF2

Cytogenetic location: 7p11.2 Genomic coordinates (GRCh38): 7:56,064,286-56,087,946 (from NCBI)

This gene has 23 transcripts (splice variants), 105 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 45.6), kidney (RPKM 41.8) and 25 other tissues.

Summary

The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by Enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

SUMF2 Products (9)

mRNA	Protein	Name
NM_001042468.3	NP_001035933.3	inactive C-alpha-formylglycine-generating enzyme 2 isoform a precursor
NM_001042469.3	NP_001035934.3	inactive C-alpha-formylglycine-generating enzyme 2 isoform c precursor
NM_001042470.3	NP_001035935.3	inactive C-alpha-formylglycine-generating enzyme 2 isoform d precursor
NM_001130069.4	NP_001123541.2	inactive C-alpha-formylglycine-generating enzyme 2 isoform e precursor
NM_001146333.3	NP_001139805.1	inactive C-alpha-formylglycine-generating enzyme 2 isoform g
NM_001366647.2	NP_001353576.1	inactive C-alpha-formylglycine-generating enzyme 2 isoform h precursor
NM_001366648.2	NP_001353577.1	inactive C-alpha-formylglycine-generating enzyme 2 isoform i precursor
NM_001366649.2	NP_001353578.1	inactive C-alpha-formylglycine-generating enzyme 2 isoform j
NM_015411.4	NP_056226.3	inactive C-alpha-formylglycine-generating enzyme 2 isoform b precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	15962010	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15962010	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18266766	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUMF2 Protein Structure

FGE-sulfatase

0
100
200
300
358 a.a.

Protein Preferred Names	Protein Names
inactive C-alpha-formylglycine-generating enzyme 2	C-alpha-formyglycine-generating enzyme 2

SUMF2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	SUMF2	Q8NBJ7	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	SUMF2	Q8NBJ7	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	SUMF2	Q8NBJ7	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	SUMF2	Q8NBJ7	CTSD	Homo sapiens	P07339	Y2H Pooling	32814053
Intra	SUMF2	Q8NBJ7	CTSD	Homo sapiens	P07339	Validated Y2H	32814053
Intra	SUMF2	Q8NBJ7	CTSD	Homo sapiens	P07339	Y2H Array	32814053
Intra	SUMF2	Q8NBJ7	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	SUMF2	Q8NBJ7	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	SUMF2	Q8NBJ7	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	SUMF2	Q8NBJ7	ap3a_sars2	SARS-CoV-2	P0DTC3	Y2H Array	36217030
Intra	SUMF2	Q8NBJ7	IDS	Homo sapiens	P22304	Anti Tag CoIP	15962010
Intra	SUMF2	Q8NBJ7	SUMF1	Homo sapiens	Q8NBK3	Comig Non-Denat Gel	15962010
Intra	SUMF2	Q8NBJ7	SUMF1	Homo sapiens	Q8NBK3	Anti Tag CoIP	15962010
Intra	SUMF2	Q8NBJ7	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	SUMF2	Q8NBJ7	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	SUMF2	Q8NBJ7	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	SUMF2	Q8NBJ7	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	SUMF2	Q8NBJ7	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	SUMF2	Q8NBJ7	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	SUMF2	Q8NBJ7	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	SUMF2	Q8NBJ7	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	SUMF2	Q8NBJ7	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	SUMF2	Q8NBJ7	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	SUMF2	Q8NBJ7	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	SUMF2	Q8NBJ7	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	SUMF2	Q8NBJ7	ccsb_9919	Homo sapiens	EBI-25847655	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

SUMF2 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P810081	SUMF2 Antibody (YA9425)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human

Related Diseases

Diseases	Alias
Multiple Sulfatase Deficiency	Mucosulfatidosis MSD Sulfatidosis, Juvenile, Austin Type Multiple Sulfatase Deficiency Disease Juvenile Sulfatidosis, Austin Type Juvenile Sulfatidosis Sulfatidosis Juvenile, Austin Type Austin Syndrome Sulfatidosis Juvenile Austin Type Sulfatase Deficiency, Multiple
Phosphoserine Phosphatase Deficiency	PSPHD Deficiency Of Phosphoserine Phosphatase Psph Deficiency 3-Phosphoserine Phosphatase Deficiency, Infantile/Juvenile Form Psph Deficiency, Infantile/Juvenile Form Deficiency, Phosphoserine Phosphatase
Serine Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS14024	SUMF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SUMF2	MGD	MGI:1915152
Bos taurus	SUMF2	VGNC	VGNC:35472
Felis catus	SUMF2	VGNC	VGNC:80686
Rattus norvegicus	SUMF2	RGD	RGD:1563253
Macaca mulatta	SUMF2	VGNC	VGNC:78180
Canis familiaris	SUMF2	VGNC	VGNC:46983
Others	SUMF2	NCBI