INTS6 - integrator complex subunit 6 Gene

Also Known as HDB; INT6; DBI-1; DDX26; DICE1; DDX26A; Notchl2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26512

About INTS6

Cytogenetic location: 13q14.3 Genomic coordinates (GRCh38): 13:51,334,405-51,453,036 (from NCBI)

This gene has 20 transcripts (splice variants), 189 orthologues and 11 paralogues. Broad expression in testis (RPKM 13.0), thyroid (RPKM 3.7) and 25 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and is located in the critical region of loss of heterozygosity (LOH). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2015]

INTS6 Products (4)

mRNA Protein Name
NM_001039937.2 NP_001035026.1 integrator complex subunit 6 isoform b
NM_001039938.2 NP_001035027.1 integrator complex subunit 6 isoform c
NM_001306091.2 NP_001293020.1 integrator complex subunit 6 isoform 4
NM_012141.3 NP_036273.1 integrator complex subunit 6 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
16239144 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in snRNA processing IDA
IDA: Inferred from direct assay
16239144 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of integrator complex IDA
IDA: Inferred from direct assay
16239144 GOA
located in nucleus IDA
IDA: Inferred from direct assay
23904267 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INTS6 Protein Structure

VWA_2

VWA_2: von Willebrand factor type A domain (4 - 210)

INT_SG_DDX_CT_C

INT_SG_DDX_CT_C: INTS6/SAGE1/DDX26B/CT45 C-terminus (806 - 870)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 887 a.a.
Protein Preferred Names Protein Names

integrator complex subunit 6

  • DEAD box protein

INTS6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
INTS6 Q9UL03 MCM7 Homo sapiens P33993
Anti Tag CoIP
17310990
Intra
INTS6 Q9UL03 MCM7 Homo sapiens P33993
Y2H
17310990
Intra
INTS6 Q9UL03 MCM7 Homo sapiens P33993
Anti Bait CoIP
17310990
Intra
INTS6 Q9UL03 MCM7 Homo sapiens P33993
Pull Down
17310990
Cross: Cross-species interaction Intra: Intraspecies interaction

INTS6 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P810053 DICE1 Antibody (YA9397) ICC/IF, IF-Tissue, IHC-P, ELISA human, mouse, rat

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS06856 INTS6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus INTS6 VGNC VGNC:30232
Macaca mulatta INTS6 VGNC VGNC:103829
Canis familiaris INTS6 VGNC VGNC:42054
Felis catus INTS6 VGNC VGNC:97467
Rattus norvegicus INTS6 RGD RGD:1309480
Mus musculus INTS6 MGD MGI:1202397
Others INTS6 NCBI