CD209 - CD209 molecule Gene

Also Known as CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; hDC-SIGN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 30835

About CD209

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:7,739,993-7,747,534 (from NCBI)

This gene has 11 transcripts (splice variants), 891 orthologues, 14 paralogues and is associated with 68 phenotypes. Broad expression in placenta (RPKM 11.4), lymph node (RPKM 9.5) and 17 other tissues.

Summary

This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including leprosy and tuberculosis mycobacteria, the Ebola, hepatitis C, HIV-1 and Dengue viruses, and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CLEC4M (Gene ID: 10332), also known as L-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression on the surface of dendritic cells. Polymorphisms in the neck region are associated with protection from HIV-1 Infection, while single nucleotide polymorphisms in the promoter of this gene are associated with differing resistance and susceptibility to and severity of infectious disease, including rs4804803, which is associated with SARS severity. [provided by RefSeq, May 2020]

CD209 Products (7)

mRNA	Protein	Name
NM_001144893.2	NP_001138365.1	CD209 antigen isoform 5
NM_001144894.2	NP_001138366.1	CD209 antigen isoform 6
NM_001144895.2	NP_001138367.1	CD209 antigen isoform 7
NM_001144896.2	NP_001138368.1	CD209 antigen isoform 3
NM_001144897.2	NP_001138369.1	CD209 antigen isoform 4
NM_001144899.2	NP_001138371.1	CD209 antigen isoform 8
NM_021155.4	NP_066978.1	CD209 antigen isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12609975	GOA
enables virus receptor activity	IDA IDA: Inferred from direct assay	22156524	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in B cell adhesion	IDA IDA: Inferred from direct assay	12421943	GOA
involved in positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	12421943	GOA
involved in positive regulation of viral life cycle	IMP IMP: Inferred from mutant phenotype	22673088	GOA
acts upstream of or within regulation of T cell proliferation	IDA IDA: Inferred from direct assay	12456590	GOA
involved in symbiont entry into host cell	IDA IDA: Inferred from direct assay	24623090	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	24942581	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12421943	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD209 Protein Structure

Lectin_C

0
100
200
300
404 a.a.

Protein Preferred Names	Protein Names
CD209 antigen	C-type lectin domain family 4 member L

CD209 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	CD209	Q9NNX6	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	25416956
Intra	CD209	Q9NNX6	VAC14	Homo sapiens	Q08AM6	Y2H Array	29892012
Cross	CD209	Q9NNX6	Q03463-PRO_0000278734	Hepatitis C virus	Q03463-PRO_0000278734	SPR	12609975

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD209 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P70110	DC-SIGN/CD209 Protein, Human (HEK293, Fc)	Q9NNX6-1 (Q59-A404)	≥ 95%, as determined by reducing SDS-PAGE.

CD209 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P83614	CD209 Antibody (YA3359)	WB	Human
HY-P84813	CD209 Antibody (YA4510)	WB, FC, ELISA	Human
HY-P84813A	CD209 Antibody (YA4510)(PBS only)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Dengue Virus	Dengue Virus, Susceptibility To Dengue Fever, Protection Against Dengue Fever
Human Immunodeficiency Virus Type 1	Aids Hiv/Aids Aids, Delayed/Rapid Progression To Hiv-1, Susceptibility To Hiv-1 Viremia, Susceptibility To Human Immunodeficiency Virus Type 1, Susceptibility To Hiv-1 Aids, Slow Progression To Rapid Progression To Aids From Hiv1 Infection Hiv1 Infection, Resistance To Hiv1 Infection Hiv-1 Viremia Aids, Resistance To Aids, Rapid Progression To Hiv/Aids, Susceptibility To Hiv-1, Resistance To Hiv1, Resistance To Hiv1 Hiv-1 Disease, Delayed Progression Of Hiv-1 Disease, Rapid Progression Of Hiv Infection, Resistance To Hiv Type 1, Susceptibility To Hiv Type 1 Hiv-1 Infection Human Immunodeficiency Virus I Infection Acquired Immunodeficiency Syndrome Hiv-Infection/Aids
Rift Valley Fever	Rfv - [Rift Valley Fever]
Japanese Encephalitis	Japanese B Encephalitis Je Encephalitis Japanese Encephalitis, Japanese Russian Autumnal Encephalitis Je - [Japanese Encephalitis] Japanese Encephalitis Virus Disease Jbe - [Japanese B Encephalitis} B Type Encephalitis
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Measles	Rubeola Morbilli Measles Nos Koplik Spots
West Nile Virus	West Nile Virus, Susceptibility To Wnv Wnv, Susceptibility To West Nile Viral Infection Encephalitis, West Nile Fever West Nile Fever
Dengue Disease	Dengue Fever Dengue Df Dengue Shock Syndrome Dengue Virus Infection Breakbone Fever Classic Dengue Classical Dengue Dengue Hemorrhagic Fever Hemorrhagic Dengue Philippine Hemorrhagic Fever Singapore Hemorrhagic Fever Thai Hemorrhagic Fever Severe Dengue Dengue Fever Without Warning Signs Dengue Haemorrhagic Fever Grade 1 Dengue Haemorrhagic Fever Without Warning Signs Bangkok Haemorrhagic Fever Singapore Haemorrhagic Fever Thailand Haemorrhagic Fever Southeast Asia Haemorrhagic Fever Dhf -[Dengue Haemorrhagic Fever] Dengue Fever With Warning Signs Dengue Haemorrhagic Fever With Warning Signs Dengue Haemorrhagic Fever Grade 2 Philippine Haemorrhagic Fever
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Syphilis	Chancre Syphilitic Chancre
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Hand, Foot And Mouth Disease	Vesicular Stomatitis And Exanthem
Zika Fever	Zika Virus Infection Zika Virus Disease Zika Virus Zika Virus Fever Mosquito-Borne Viral Fever, Zika
Papilloma	Papillomatosis
Lymphadenitis	Acute Lymphadenitis Chronic Lymphadenitis Adenitis Chronic Adenitis Acute Adenitis Inflammation Of Lymph Node Adenitis Nos Inflammation Of Gland Lymphatic Gland Inflammation Lymph Gland Inflammation Polyadenitis Chronic Adenitis Of Any Lymph Node Except Mesenteric Chronic Lymphadenitis Except Mesenteric Chronic Non-Specific Lymphadenitis
Human Immunodeficiency Virus Infectious Disease	Hiv Infections
Paracoccidioidomycosis	Mucocutaneous-Lymphangitic Paracoccidioidomycosis Paracoccidioidal Mycosis Lobo Disease Lutz-Splendore-Almeida Disease Pcm Paracoccidioidal Granuloma South American Blastomycosis Lobomycosis Brazilian Blastomycosis Lutz Disease Brazilian Blastomycotic South American Blastomyces Infection Paracoccidioides Brasiliensis Infection Paracoccidioidomycosis Unspecified
Lymphocytic Choriomeningitis	Lcm Lymphocytic Meningitis Lymphocytic Choriomeningitis Virus Encephalomyelitis Lymphocytic Meningoencephalitis Non-Arthropod Borne Lymphocytic Choriomeningitis Lcm - [Lymphocytic Choriomeningitis] Benign Lymphocytic Meningitis Meningitis Due To Lymphocytic Choriomeningitis Virus
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculoma Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Disease By Infectious Agent	Infectious Disease Infectious Diseases
Severe Acute Respiratory Syndrome	Sars Sars-Cov Infection Sars-1 Sar Deficiency Sars - [Severe Acute Respiratory Syndrome]
Aspergillosis	Aspergillosis, Susceptibility To Infection Due To Aspergillus Aspergilloma Aspergillus Nodule Simple Aspergilloma Aspergillus Aspergillus Flavus Infection Aspergillus Fumigatus Infection Aspergillus Infection Infection By Aspergillus Fumigatus Intracavitary Aspergillus Fungus Ball Aspergillus Terreus
Chikungunya	Chikungunya Fever Arbovirus A Chikungunya Type Chik Chikv Infection Ck Chikungunya Virus Infection Chikungunya Haemorrhagic Fever Chikungunya Viral Disease Chikungunya Mosquito-Borne Viral Fever
Dengue Hemorrhagic Fever	Severe Dengue Dengue Haemorrhagic Fever Dhf Severe Dengue Haemorrhagic Fever Severe Dengue Fever Dengue Shock Syndrome
Tick-Borne Encephalitis	Siberian Tick-Borne Encephalitis Encephalitis, Tick-Borne Central European Encephalitis Far Eastern Tbe Russian Spring-Summer Encephalitis Taiga Encephalitis West-Siberian Encephalitis Western European Tick-Borne Encephalitis Tbe Encephalitis Tick-Borne Encephalitis, Central European Encephalitis, Far Eastern Russian
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Mouth Disease	Mouth Diseases Mouth Disorders
Dengue Shock Syndrome	Dss
Ebola Hemorrhagic Fever	Ebola Virus Disease Viral Hemorrhagic Fever Hemorrhagic Fever, Ebola Ebola Ehf Ebola Fever Hemorrhagic Fevers, Viral Ebola Haemorrhagic Fever Ebod - [Ebola Disease] Evd - [Ebola Virus Disease] Ebola Virus Haemorrhagic Fever Vhf - [Viral Haemorrhagic Fever] Nos Viral Haemorrhagic Fever, Not Otherwise Specified
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Invasive Aspergillosis	Aspergillosis Invasive
Miyoshi Muscular Dystrophy 3	MMD3 Miyoshi Myopathy 3 Distal Anoctaminopathy Miyoshi Muscular Dystrophy Type 3 Dystrophy, Muscular, Miyoshi, Type 3
Cutaneous Leishmaniasis	Diffuse Cutaneous Leishmaniasis Asian Desert Cutaneous Leishmaniasis Leishmaniasis, Cutaneous Leproid Leishmaniasis Leishmaniasis Diffuse Cutaneous Leishmaniasis Cutaneous Ethiopian Cutaneous Leishmaniasis Old World Cutaneous Leishmaniasis
Tuberculoid Leprosy	Smooth Leprosy Type T Leprosy Leprosy Tuberculoid Leprosy, Tuberculoid
West Nile Fever
Murray Valley Encephalitis	Australian Encephalitis Australian X Disease Encephalitis Australia Murray River Encephalitis Australian Arboencephalitis Australian X Disorder Mve - [Murray Valley Encephalitis]
Lassa Fever	Lf Lassa Hemorrhagic Fever Lf - [Lassa Fever]
Lepromatous Leprosy	Leprosy, Lepromatous Type L Leprosy Leprosy Lepromatous
Leprosy 3	Leprosy Leprosy, Susceptibility To, 3 Hansen'S Disease Leprosy, Susceptibility To Hansen Disease Infection Due To Mycobacterium Leprae LPRS3 Leprosy, Type 3 Anaesthesia Leprosy Anaesthetic Leprosy Maculoanaesthetic Leprosy Macular Leprosy Leprosy Unspecified
Fungal Infectious Disease	Mycoses Mycosis
Opportunistic Mycosis	Opportunistic Mycoses Opportunistic Systemic Mycoses
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Primary Bacterial Infectious Disease
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-P991424	GSK2618960	Inhibitor	95.66%	Phase 2

Pre-clinical Phase

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-175421	ArMan	Activator	/	Unkown
HY-RS02209	CD209 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P99122	Anti-Mouse CD209b Antibody (22D1)	Inhibitor	99.00%	Unkown
HY-P990398	Anti-DC-SIGN/CD209 Antibody		99.51%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CD209	RGD	RGD:1561104
Others	CD209	NCBI