MX1 - MX dynamin like GTPase 1 Gene

Also Known as MX; MxA; IFI78; IFI-78K; lncMX1-215

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4599

About MX1

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:41,420,558-41,459,214 (from NCBI)

This gene has 48 transcripts (splice variants), 196 orthologues and 6 paralogues. Ubiquitous expression in spleen (RPKM 25.6), salivary gland (RPKM 13.5) and 24 other tissues.

Summary

This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular Antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

MX1 Products (4)

mRNA	Protein	Name
NM_001144925.2	NP_001138397.1	interferon-induced GTP-binding protein Mx1 isoform a
NM_001178046.3	NP_001171517.1	interferon-induced GTP-binding protein Mx1 isoform a
NM_001282920.1	NP_001269849.1	interferon-induced GTP-binding protein Mx1 isoform b
NM_002462.5	NP_002453.2	interferon-induced GTP-binding protein Mx1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	20428112	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15047845	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in antiviral innate immune response	IEP IEP: Inferred from expression pattern	25930096	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	21478870	GOA
involved in interleukin-27-mediated signaling pathway	IEP IEP: Inferred from expression pattern	32270034	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	14687945	GOA
involved in response to virus	IMP IMP: Inferred from mutant phenotype	15047845	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21859714	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15047845	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MX1 Protein Structure

Dynamin_N

Dynamin_M

GED

0
200
400
600
662 a.a.

Protein Preferred Names	Protein Names
interferon-induced GTP-binding protein Mx1	interferon-induced protein p78

MX1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	MX1	P20591	CAB39L	Homo sapiens	Q9H9S4	Validated Y2H	25416956
Intra	MX1	P20591	CAB39L	Homo sapiens	Q9H9S4	Y2H Array	25416956
Intra	MX1	P20591	MCCD1	Homo sapiens	P59942	Y2H Prey Pooling	32296183
Intra	MX1	P20591	MCCD1	Homo sapiens	P59942	Validated Y2H	32296183
Intra	MX1	P20591	MCCD1	Homo sapiens	P59942	Y2H Array	32296183
Intra	MX1	P20591	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183
Intra	MX1	P20591	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
Intra	MX1	P20591	LGALS3BP	Homo sapiens	Q08380	Pull Down	30833792
Intra	MX1	P20591	BCS1L	Homo sapiens	Q9Y276	Anti Tag CoIP	33961781
Intra	MX1	P20591	BCS1L	Homo sapiens	Q9Y276	Anti Tag CoIP	28514442
Intra	MX1	P20591	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956
Intra	MX1	P20591	TRPC6	Homo sapiens	Q9Y210	Y2H	15757897
Intra	MX1	P20591	MX1	Homo sapiens	P20591	Anti Tag CoIP	20428112
Intra	MX1	P20591	MX1	Homo sapiens	P20591	Solution Sedimentation	20428112
Intra	MX1	P20591	MX1	Homo sapiens	P20591	GTPase Assay	25295396
Intra	MX1	P20591	GCD7	Saccharomyces cerevisiae	P32502	Y2H Array	27107014
Intra	MX1	P20591	MX1	Homo sapiens	P20591	Validated Y2H	32296183
Intra	MX1	P20591	MX1	Homo sapiens	P20591	Y2H Array	25416956
Intra	MX1	P20591	MX1	Homo sapiens	P20591	X-Ray Diffraction	20428112
Intra	MX1	P20591	MX1	Homo sapiens	P20591	X-Ray Diffraction	25295396
Intra	MX1	P20591	MX1	Homo sapiens	P20591	Y2H Array	32296183
Intra	MX1	P20591	MX1	Homo sapiens	P20591	Y2H Prey Pooling	32296183
Intra	MX1	P20591	MX1	Homo sapiens	P20591	SLS	25295396
Intra	MX1	P20591	MX1	Homo sapiens	P20591	GMS	20428112
Intra	MX1	P20591	TRPC4	Homo sapiens	Q9UBN4	Pull Down	15757897

Cross: Cross-species interaction Intra: Intraspecies interaction

MX1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P86136	MX1 Antibody (YA5828)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Viral Encephalitis	Epidemic Encephalitis Encephalitis Viral Encephalitis, Arbovirus Arbovirus Encephalitis Postviral Encephalitis Nos Equine Encephalitis Tick-Borne Encephalitis Viral Encephalitis Transmitted By Tick Mosquito-Borne Encephalitis Acute Haemorrhagic Encephalitis Acute Idiopathic Encephalitis Chronic Viral Encephalitis Endemic Encephalitis Subacute Viral Encephalitis Viral Haemorrhagic Encephalitis Viral Nonepidemic Encephalitis Nonepidemic Encephalitis
Subacute Sclerosing Panencephalitis	SSPE Dawson Encephalitis Immunosuppressive Measles Encephalitis Subacute Sclerosing Leukoencephalitis Panencephalitis, Subacute Sclerosing Subacute Sclerosing Leukoencephalopathy Van Bogaert'S Sclerosing Leukoencephalitis Dawson Disease Subacute Inclusion Body Encephalitis Van Bogaert Disease Van Bogaert Encephalitis Measles Inclusion Body Encephalitis Mibe - [Measles Inclusion Body Encephalitis] Sspe - [Subacute Sclerosing Panencephalitis] Van Bogaert Leukoencephalitis Van Bogaert Sclerosing Leukoencephalitis Dawson Inclusion Body Encephalitis Van Bogaert Sclerosing Leukoencephalopathy Bodechtel Guttman Disease Diffuse Sclerosing Encephalitis
Lichen Planus	Lichen Ruber Planus Lichen, Ruber Planus Ruber Planus Lp - [Lichen Planus] Lichen Planus Of Wilson Wilson Lichen Ruber
Biliary Atresia	Congenital Biliary Atresia Isolated Biliary Atresia Isolated Atresia Of Bile Ducts Non-Syndromic Biliary Atresia Atresia Of Bile Duct Biliary Atresia, Congenital Atresia Of Bile Ducts Bile Duct Atresia Congenital Bile Duct Atresia Ba - [Biliary Atresia] Impervious Bile Duct Atresia Of Common Duct Biliary Duct Atresia Bile Ductal Atresia Cystic Duct Atresia
Relapsing-Remitting Multiple Sclerosis	Relapsing-Remitting Ms Relapsing Remitting Multiple Sclerosis Multiple Sclerosis, Relapsing-Remitting Rrms Multiple Sclerosis Relapsing-Remitting
Pityriasis Lichenoides
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Rabies	Lyssa Hydrophobia St Hubert Disease
Swine Influenza	Influenza Due To Influenza A Virus Subtype H1n1
Viral Hepatitis	Animal Viral Hepatitis Hepatitis, Viral, Animal Human Viral Hepatitis Viral Hepatitis With Hepatic Coma
Rift Valley Fever	Rfv - [Rift Valley Fever]
Hepatitis B	Chronic Hepatitis B Hepatitis B Infection Serum Hepatitis HBV Hepatitis B Chronic Hbv, Susceptibility To Hepatitis B, Chronic Chronic Hepatitis B Without Delta Agent Chronic Hbv - [Hepatitis B Virus] Infection Hepatitis B Nos Chronic Type B Viral Hepatitis Hep B Nos
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Cowpox	Yaba
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Acute Generalized Exanthematous Pustulosis	Agep Pustular Drug Eruption Toxic Pustuloderma
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Avian Influenza	Bird Flu Influenza In Birds Avian Flu
Mumps	Parotitis Due To Mumps Virus Mumps Nos Epidemic Parotitis Infectious Parotitis
Mouth Disease	Mouth Diseases Mouth Disorders
Severe Acute Respiratory Syndrome	Sars Sars-Cov Infection Sars-1 Sar Deficiency Sars - [Severe Acute Respiratory Syndrome]
Stomatitis
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Cutaneous Lupus Erythematosus	Lupus Erythematosus, Cutaneous Lupus Erythematosus Cutaneous
Adult Dermatomyositis	Adult Onset Dermatomyositis Adult Type Dermatomyositis
Childhood Type Dermatomyositis	Juvenile Dermatomyositis Juvenile Dm Childhood Dermatomyositis Amyopathic Dermatomyositis Adm Dermatomyositis Sine Myositis Dermatomyositis, Childhood Type
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Hantavirus Hemorrhagic Fever With Renal Syndrome	Hemorrhagic Fever, Russian Hemorrhagic Nephrosonephritis Hfrs Puumala Virus Nephropathy Hemorrhagic Fever With Renal Syndrome
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Scrapie
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Human Immunodeficiency Virus Infectious Disease	Hiv Infections
Pediculus Humanus Corporis Infestation	Body Louse Infestation Pediculus Corporis Pediculus Humanus Infestation
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Potocki-Shaffer Syndrome	Proximal 11p Deletion Syndrome Chromosome 11p11.2 Deletion Syndrome Pss 11p11.2 Deletion P11pds Defect11 Syndrome Deletion Of Chromosome 11p11.2 POSHS
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-106031	F-14512	Inhibitor	98.04%	Phase 2
HY-12098	Verubulin hydrochloride	Inhibitor	98.71%	Phase 2
HY-106401	Penclomedine		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (13)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-160229	ssRNA40 sodium		98.34%	Unkown
HY-N0167	Gynostemma Extract	Inhibitor	99.92%	Unkown
HY-123805	KIN1400		98.1%	Unkown
HY-10615	A-620223	Inhibitor	98.84%	Unkown
HY-162465	BDW568	Agonist	99.4%	Unkown
HY-RS18454	Mx1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-106031A	F-14512 hydrochloride	Inhibitor	/	Unkown
HY-131438	GI-149893	Inhibitor	/	Unkown
HY-14687	(rac)-Talazoparib	Inhibitor	/	Unkown
HY-181796	TLR7 antagonist-1		/	Unkown
HY-RS08859	MX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-121372	Lactandrate		/	Unkown
HY-RS24935	Mx1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MX1	VGNC	VGNC:31770
Macaca mulatta	MX1	VGNC	VGNC:75086
Canis familiaris	MX1	VGNC	VGNC:43511
Rattus norvegicus	MX1	RGD	RGD:3127
Felis catus	MX1	VGNC	VGNC:108368
Others	MX1	NCBI