GTSE1 - G2 and S-phase expressed 1 Gene

Also Known as B99

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51512

About GTSE1

Cytogenetic location: 22q13.31 Genomic coordinates (GRCh38): 22:46,296,870-46,330,810 (from NCBI)

This gene has 4 transcripts (splice variants), 178 orthologues and 1 paralogue. Broad expression in testis (RPKM 2.8), lymph node (RPKM 2.7) and 15 other tissues.

Summary

The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce Apoptosis. [provided by RefSeq, Jul 2008]

GTSE1 Products (1)

mRNA Protein Name
NM_016426.7 NP_057510.5 G2 and S phase-expressed protein 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
20577264 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasmic microtubule IDA
IDA: Inferred from direct assay
10974554 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTSE1 Protein Structure

GTSE1_N

GTSE1_N: G-2 and S-phase expressed 1 (27 - 171)

  • 0
  • 200
  • 400
  • 600
  • 739 a.a.
Protein Preferred Names Protein Names

G2 and S phase-expressed protein 1

  • G-2 and S-phase expressed 1

GTSE1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
GTSE1 Q9NYZ3 PLK1 Homo sapiens P53350
Protein Kinase Assay
20577264
Intra
GTSE1 Q9NYZ3 PLK1 Homo sapiens P53350
Anti Bait CoIP
20577264
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Astroblastoma, Mn1-Altered

  • Cns High-Grade Neuroepithelial Tumors With Mn1 Alteration
Arthrogryposis Multiplex Congenita 2, Neurogenic Type

  • Arthrogryposis Multiplex Congenita, Neurogenic Type

  • Amcn

  • Arthrogryposis Multiplex Congenita Neurogenic Type

  • AMC2

  • Amc, Neurogenic Type

  • Neurogenic-Type Arthrogryposis Multiplex Congenita-2

  • Amc Neurogenic Type

  • Neurogenic Type Of Amc

  • Neurogenic Arthrogryposis Multiplex Congenita

  • Arthrogryposis Multiplex Congenita, Neurogenic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-162808 GTSE1-IN-1 98.07% Unkown
HY-RS05913 GTSE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GTSE1 RGD RGD:1563164
Canis familiaris GTSE1 VGNC VGNC:41559
Bos taurus GTSE1 VGNC VGNC:29711
Macaca mulatta GTSE1 VGNC VGNC:73162
Mus musculus GTSE1 MGD MGI:1352755
Felis catus GTSE1 VGNC VGNC:62738
Others GTSE1 NCBI