Cltc - clathrin heavy chain Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54241

Summary

Enables several functions, including ankyrin binding activity; heat shock protein binding activity; and protein C-terminus binding activity. Involved in Golgi organization; endocytosis; and mitotic cell cycle. Located in T-tubule and spindle. Part of clathrin coat. Is extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 56. Orthologous to human CLTC (clathrin heavy chain). [provided by Alliance of Genome Resources, Apr 2022]

Cltc Products (1)

mRNA Protein Name
NM_019299.2 NP_062172.2 clathrin heavy chain 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables ankyrin binding IDA
IDA: Inferred from direct assay
10585476 RGD
enables heat shock protein binding IDA
IDA: Inferred from direct assay
17978091 RGD
enables peptide binding IDA
IDA: Inferred from direct assay
1490999 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11102472 RGD
enables protein serine/threonine kinase binding IPI
IPI: Inferred from physical interaction
20802490 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in Golgi organization IMP
IMP: Inferred from mutant phenotype
17065556 RGD
involved in mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
15858577 RGD
involved in receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
15858577 RGD
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
16982422 RGD
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
16982422 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in T-tubule IDA
IDA: Inferred from direct assay
7536412 RGD
part of clathrin coat IDA
IDA: Inferred from direct assay
1490999 RGD
is active in extrinsic component of synaptic vesicle membrane IDA
IDA: Inferred from direct assay
1325974 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
7536412 RGD
located in spindle IDA
IDA: Inferred from direct assay
15858577 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

clathrin heavy chain 1

  • clathrin, heavy chain (Hc)

  • clathrin, heavy polypeptide (Hc)

Cltc Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Cross
Cltc P11442 OCRL Homo sapiens Q01968
Pull Down
19536138
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS02845 CLTC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21314 Cltc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27833 Cltc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cltc NCBI NCBI:1213