ASAP3 - ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Gene

Also Known as ACAP4; UPLC1; CENTB6; DDEFL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55616

About ASAP3

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:23,428,563-23,484,631 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 114 orthologues and 28 paralogues. Ubiquitous expression in ovary (RPKM 21.1), skin (RPKM 19.0) and 23 other tissues.

Summary

This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in Cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

ASAP3 Products (2)

mRNA Protein Name
NM_001143778.2 NP_001137250.1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform b
NM_017707.4 NP_060177.2 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
18400762 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19380743 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
18400762 GOA
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
18400762 GOA
involved in regulation of stress fiber assembly IMP
IMP: Inferred from mutant phenotype
18400762 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in focal adhesion IDA
IDA: Inferred from direct assay
18400762 GOA
located in ruffle IDA
IDA: Inferred from direct assay
18400762 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASAP3 Protein Structure

PH

PH: PH domain (304 - 392)

ArfGap

ArfGap: Putative GTPase activating protein for Arf (429 - 542)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (590 - 676)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 903 a.a.
Protein Preferred Names Protein Names

arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

  • ARF6 GTPase-activating protein

ASAP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ASAP3 Q8TDY4 UBE3A Homo sapiens Q05086-2
Validated Y2H
25416956
Intra
ASAP3 Q8TDY4 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
ASAP3 Q8TDY4 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
ASAP3 Q8TDY4 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
Intra
ASAP3 Q8TDY4 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra
ASAP3 Q8TDY4 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra
ASAP3 Q8TDY4 NHERF4 Homo sapiens Q86UT5-3
Y2H Prey Pooling
32296183
Intra
ASAP3 Q8TDY4 NHERF4 Homo sapiens Q86UT5-3
Y2H Array
32296183
Intra
ASAP3 Q8TDY4 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra
ASAP3 Q8TDY4 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra
ASAP3 Q8TDY4 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra
ASAP3 Q8TDY4 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
ASAP3 Q8TDY4 TFCP2 Homo sapiens Q12800
Y2H Prey Pooling
25416956
Intra
ASAP3 Q8TDY4 NHERF4 Homo sapiens Q86UT5
Validated Y2H
25416956
Intra
ASAP3 Q8TDY4 NHERF4 Homo sapiens Q86UT5
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS01057 ASAP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21485 Asap3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28003 Asap3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ASAP3 VGNC VGNC:99849
Rattus norvegicus ASAP3 RGD RGD:1593929
Mus musculus ASAP3 MGD MGI:2684986
Bos taurus ASAP3 VGNC VGNC:54406
Felis catus ASAP3 VGNC VGNC:59954
Others ASAP3 NCBI