SLAIN2 - SLAIN motif family member 2 Gene

Also Known as KIAA1458

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57606

About SLAIN2

Cytogenetic location: 4p11 Genomic coordinates (GRCh38): 4:48,341,529-48,426,201 (from NCBI)

This gene has 5 transcripts (splice variants), 199 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 22.9), esophagus (RPKM 14.0) and 25 other tissues.

Summary

Involved in cytoplasmic microtubule organization; microtubule nucleation; and positive regulation of microtubule polymerization. Located in centrosome and cytosol. Colocalizes with microtubule plus-end. [provided by Alliance of Genome Resources, Apr 2022]

SLAIN2 Products (1)

mRNA Protein Name
NM_020846.2 NP_065897.1 SLAIN motif-containing protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
21646404 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cytoplasmic microtubule organization IMP
IMP: Inferred from mutant phenotype
21646404 GOA
involved in microtubule nucleation IMP
IMP: Inferred from mutant phenotype
21646404 GOA
involved in positive regulation of microtubule polymerization IMP
IMP: Inferred from mutant phenotype
21646404 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
21646404 GOA
colocalizes with microtubule plus-end IDA
IDA: Inferred from direct assay
21646404 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLAIN2 Protein Structure

SLAIN

SLAIN: SLAIN motif-containing family (130 - 581)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 581 a.a.
Protein Preferred Names Protein Names

SLAIN motif-containing protein 2

SLAIN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SLAIN2 Q9P270 CKAP5 Homo sapiens Q14008
Anti Tag CoIP
26496610
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Schizophrenia 3

  • SCZD3

  • Schizophrenia Susceptibility Locus, Chromosome 6-Related

  • Schizophrenia 3 With Or Without An Affective Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12978 SLAIN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SLAIN2 RGD RGD:1311593
Felis catus SLAIN2 VGNC VGNC:65176
Mus musculus SLAIN2 MGD MGI:1923241
Bos taurus SLAIN2 VGNC VGNC:34652
Canis familiaris SLAIN2 VGNC VGNC:46205
Macaca mulatta SLAIN2 VGNC VGNC:107198
Others SLAIN2 NCBI