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RPL31 - ribosomal protein L31 Gene

Also Known as L31

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6160

About RPL31

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:101,002,289-101,019,724 (from NCBI)

This gene has 11 transcripts (splice variants), 157 orthologues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 450.2), bone marrow (RPKM 284.8) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RPL31 Products (3)

mRNA	Protein	Name
NM_000993.5	NP_000984.1	60S ribosomal protein L31 isoform 1
NM_001098577.3	NP_001092047.1	60S ribosomal protein L31 isoform 2
NM_001099693.2	NP_001093163.1	60S ribosomal protein L31 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24725430	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cytoplasmic translation	IDA IDA: Inferred from direct assay	25957688	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	25957688	GOA
part of cytosolic large ribosomal subunit	IPI IPI: Inferred from physical interaction	25901680	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL31 Protein Structure

Ribosomal_L31e

0
100
125 a.a.

Protein Preferred Names	Protein Names
60S ribosomal protein L31	large ribosomal subunit protein eL31

RPL31 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Cross	RPL31	P62899	N	SARS-CoV-2	P0DTC9	Y2H Array	36217030
Intra	RPL31	P62899	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	RPL31	P62899	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	RPL31	P62899	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	RPL31	P62899	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	RPL31	P62899	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	RPL31	P62899	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	RPL31	P62899	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	RPL31	P62899	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	RPL31	P62899	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	RPL31	P62899	CTCF	Homo sapiens	P49711	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome
Diamond-Blackfan Anemia 6	DBA6 Aase-Smith Syndrome Ii Aase Syndrome Aase Smith Syndrome 2 Rpl5-Related Diamond-Blackfan Anemia Anemia, Diamond-Blackfan, Type 6 Diamond-Blackfan Anemia 1
Retinitis Pigmentosa 23	RP23 Retinitis Pigmentosa-23 Retinitis Pigmentosa, Type 23 Rp23 Gene

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS12186	RPL31 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RPL31	VGNC	VGNC:81212
Mus musculus	RPL31	MGD	MGI:2149632
Rattus norvegicus	RPL31	RGD	RGD:621202
Others	RPL31	NCBI