CAPRIN2 - caprin family member 2 Gene
Also Known as EEG1; EEG-1; C1QDC1; RNG140
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 65981
About CAPRIN2
Cytogenetic location: 12p11.21
Genomic coordinates (GRCh38): 12:30,709,553-30,754,951 (from NCBI)
This gene has 44 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 12.6), brain (RPKM 7.2) and 25 other tissues.
Summary
The protein encoded by this gene may regulate the transport of mRNA. It may play a role in the differentiation of erythroblasts. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
CAPRIN2 Products (65)
| mRNA | Protein | Name |
|---|---|---|
| NM_001002259.3 | NP_001002259.1 | caprin-2 isoform 1 |
| NM_001206856.3 | NP_001193785.1 | caprin-2 isoform 4 |
| NM_001319842.2 | NP_001306771.1 | caprin-2 isoform 5 |
| NM_001319843.2 | NP_001306772.1 | caprin-2 isoform 6 |
| NM_001319844.2 | NP_001306773.1 | caprin-2 isoform 7 |
| NM_001319845.2 | NP_001306774.1 | caprin-2 isoform 8 |
| NM_001319846.2 | NP_001306775.1 | caprin-2 isoform 8 |
| NM_001385498.1 | NP_001372427.1 | caprin-2 isoform 9 |
| NM_001385499.1 | NP_001372428.1 | caprin-2 isoform 10 |
| NM_001385500.1 | NP_001372429.1 | caprin-2 isoform 11 |
| NM_001385501.1 | NP_001372430.1 | caprin-2 isoform 8 |
| NM_001385502.1 | NP_001372431.1 | caprin-2 isoform 12 |
| NM_001385503.1 | NP_001372432.1 | caprin-2 isoform 12 |
| NM_001385504.1 | NP_001372433.1 | caprin-2 isoform 13 |
| NM_001385505.1 | NP_001372434.1 | caprin-2 isoform 13 |
| NM_001385506.1 | NP_001372435.1 | caprin-2 isoform 13 |
| NM_001385507.1 | NP_001372436.1 | caprin-2 isoform 7 |
| NM_001385508.1 | NP_001372437.1 | caprin-2 isoform 14 |
| NM_001385509.1 | NP_001372438.1 | caprin-2 isoform 14 |
| NM_001385510.1 | NP_001372439.1 | caprin-2 isoform 15 |
| NM_001385511.1 | NP_001372440.1 | caprin-2 isoform 16 |
| NM_001385512.1 | NP_001372441.1 | caprin-2 isoform 16 |
| NM_001385513.1 | NP_001372442.1 | caprin-2 isoform 16 |
| NM_001385514.1 | NP_001372443.1 | caprin-2 isoform 17 |
| NM_001385515.1 | NP_001372444.1 | caprin-2 isoform 17 |
| NM_001385516.1 | NP_001372445.1 | caprin-2 isoform 39 |
| NM_001385518.1 | NP_001372447.1 | caprin-2 isoform 18 |
| NM_001385519.1 | NP_001372448.1 | caprin-2 isoform 19 |
| NM_001385520.1 | NP_001372449.1 | caprin-2 isoform 19 |
| NM_001385521.1 | NP_001372450.1 | caprin-2 isoform 20 |
| NM_001385522.1 | NP_001372451.1 | caprin-2 isoform 20 |
| NM_001385523.1 | NP_001372452.1 | caprin-2 isoform 21 |
| NM_001385524.1 | NP_001372453.1 | caprin-2 isoform 21 |
| NM_001385525.1 | NP_001372454.1 | caprin-2 isoform 21 |
| NM_001385526.1 | NP_001372455.1 | caprin-2 isoform 22 |
| NM_001385527.1 | NP_001372456.1 | caprin-2 isoform 23 |
| NM_001385528.1 | NP_001372457.1 | caprin-2 isoform 24 |
| NM_001385529.1 | NP_001372458.1 | caprin-2 isoform 24 |
| NM_001385531.1 | NP_001372460.1 | caprin-2 isoform 5 |
| NM_001385532.1 | NP_001372461.1 | caprin-2 isoform 5 |
| NM_001385533.1 | NP_001372462.1 | caprin-2 isoform 5 |
| NM_001385534.1 | NP_001372463.1 | caprin-2 isoform 5 |
| NM_001385535.1 | NP_001372464.1 | caprin-2 isoform 25 |
| NM_001385537.1 | NP_001372466.1 | caprin-2 isoform 26 |
| NM_001385538.1 | NP_001372467.1 | caprin-2 isoform 27 |
| NM_001385539.1 | NP_001372468.1 | caprin-2 isoform 28 |
| NM_001385540.1 | NP_001372469.1 | caprin-2 isoform 29 |
| NM_001385541.1 | NP_001372470.1 | caprin-2 isoform 29 |
| NM_001385542.1 | NP_001372471.1 | caprin-2 isoform 30 |
| NM_001385543.1 | NP_001372472.1 | caprin-2 isoform 31 |
| NM_001385544.1 | NP_001372473.1 | caprin-2 isoform 32 |
| NM_001385545.1 | NP_001372474.1 | caprin-2 isoform 33 |
| NM_001385546.1 | NP_001372475.1 | caprin-2 isoform 34 |
| NM_001385547.1 | NP_001372476.1 | caprin-2 isoform 35 |
| NM_001385548.1 | NP_001372477.1 | caprin-2 isoform 35 |
| NM_001385549.1 | NP_001372478.1 | caprin-2 isoform 35 |
| NM_001385550.1 | NP_001372479.1 | caprin-2 isoform 36 |
| NM_001385551.1 | NP_001372480.1 | caprin-2 isoform 36 |
| NM_001385552.1 | NP_001372481.1 | caprin-2 isoform 36 |
| NM_001385553.1 | NP_001372482.1 | caprin-2 isoform 37 |
| NM_001385554.1 | NP_001372483.1 | caprin-2 isoform 36 |
| NM_001385557.1 | NP_001372486.1 | caprin-2 isoform 38 |
| NM_001385559.1 | NP_001372488.1 | caprin-2 isoform 26 |
| NM_023925.5 | NP_076414.2 | caprin-2 isoform 2 |
| NM_032156.5 | NP_115532.3 | caprin-2 isoform 3 |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
18762581 | GOA |
| enables signaling receptor binding |
IPI
IPI: Inferred from physical interaction
|
18762581 | GOA |
| Biological Process GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| involved in negative regulation of cell growth |
IDA
IDA: Inferred from direct assay
|
14593112 | GOA |
| involved in positive regulation of canonical Wnt signaling pathway |
IDA
IDA: Inferred from direct assay
|
18762581 | GOA |
| involved in positive regulation of canonical Wnt signaling pathway |
IMP
IMP: Inferred from mutant phenotype
|
32691935 | GOA |
| involved in positive regulation of transcription by RNA polymerase II |
IDA
IDA: Inferred from direct assay
|
18762581 | GOA |
| Cellular Component GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
14593112 | GOA |
| located in mitochondrion |
IDA
IDA: Inferred from direct assay
|
14593112 | GOA |
| part of receptor complex |
IDA
IDA: Inferred from direct assay
|
18762581 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
CAPRIN2 Protein Structure
Caprin-1_C
Caprin-1_C: Cytoplasmic activation/proliferation-associated protein-1 C term (687 - 882)
C1q
C1q: C1q domain (949 - 1074)
- 0
- 200
- 400
- 600
- 800
- 1000
- 1077 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
caprin-2 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Combined Oxidative Phosphorylation Deficiency 32 |
|
|
| Mixed Fibrolamellar Hepatocellular Carcinoma |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(7)
| Art. -Nr. | Produktname |
Wirkung
|
Reinheit |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS01898 | CAPRIN2 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-165042 | 1,2-Dipalmitoyl-3-decanoyl-rac-glycerol | / | Unkown | |
| HY-170469 | 1,2-Dioleoyl-3-caprin | / | Unkown | |
| HY-179999 | 1,3-Caprin-2-stearin | / | Unkown | |
| HY-180091 | 1,3-Caprin-2-myristin | / | Unkown | |
| HY-180092 | 1,3-Caprin-2-olein | / | Unkown | |
| HY-180093 | 1,3-Caprin-2-palmitin | / | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | CAPRIN2 | RGD | RGD:1593683 |
| Bos taurus | CAPRIN2 | VGNC | VGNC:26752 |
| Macaca mulatta | CAPRIN2 | VGNC | VGNC:70599 |
| Felis catus | CAPRIN2 | VGNC | VGNC:60359 |
| Mus musculus | CAPRIN2 | MGD | MGI:2448541 |
| Canis familiaris | CAPRIN2 | VGNC | VGNC:38709 |
| Others | CAPRIN2 | NCBI |
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