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SYCP1 - synaptonemal complex protein 1 Gene

Also Known as CT8; SCP1; SCP-1; HOM-TES-14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6847

About SYCP1

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:114,854,088-114,995,370 (from NCBI)

This gene has 10 transcripts (splice variants) and 181 orthologues. Restricted expression toward testis (RPKM 18.8).

Summary

Enables double-stranded DNA binding activity. Involved in protein homotetramerization. Predicted to be located in synaptonemal complex. Predicted to be active in central element; male germ cell nucleus; and transverse filament. [provided by Alliance of Genome Resources, Apr 2022]

SYCP1 Products (3)

mRNA	Protein	Name
NM_001282541.2	NP_001269470.1	synaptonemal complex protein 1 isoform 1
NM_001282542.2	NP_001269471.1	synaptonemal complex protein 1 isoform 2
NM_003176.4	NP_003167.2	synaptonemal complex protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	29915389	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	29915389	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYCP1 Protein Structure

SCP-1

0
200
400
600
800
976 a.a.

Protein Preferred Names	Protein Names
synaptonemal complex protein 1	cancer/testis antigen 8

Related Diseases

Diseases	Alias
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Testicular Cancer	Testis Cancer Testicular Carcinoma Testicular Neoplasms Malignant Neoplasm Of Testis Childhood Neoplasm Of The Testis Neoplasm Of Testis Pediatric Testicular Neoplasm Testicular Tumor Testis Neoplasm Testicular Tumors Testicular Neoplasm Testicular Malignant Germ Cell Tumor Childhood Testicular Neoplasm Carcinoma Of The Testis Cancer Of Testis Malignant Neoplasm Of Testis, Nos Malignant Neoplasm Of Testis, Unspecified Malignant Tumour Of Testis Testicle Cancer Primary Malignant Neoplasm Of Testis
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Infertility
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS14070	SYCP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SYCP1	VGNC	VGNC:35508
Canis familiaris	SYCP1	VGNC	VGNC:47018
Mus musculus	SYCP1	MGD	MGI:105931
Macaca mulatta	SYCP1	VGNC	VGNC:78062
Felis catus	SYCP1	VGNC	VGNC:80371
Rattus norvegicus	SYCP1	RGD	RGD:3794